scholarly journals Crystal Structure of Cardiac Ryanodine Receptor N-Terminal Region Contains Unique Anion Binding Site Targeted by Disease-Associated Mutations

2014 ◽  
Vol 106 (2) ◽  
pp. 108a
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin C. Carlsson ◽  
Paolo A. Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Cardiac Ryanodine Receptor

scholarly journals The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations

Structure ◽  
2013 ◽  
Vol 21 (8) ◽  
pp. 1440-1449 ◽  
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin Cecilia Carlsson ◽  
Paolo Antonio Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Disease Mutations ◽  
Cardiac Ryanodine Receptor

Human Cardiac Ryanodine Receptor: Preparation, Crystallization and Preliminary X-ray Analysis of the N-terminal Region

2013 ◽  
Vol 20 (11) ◽  
pp. 1211-1216 ◽  
Author(s):  
L’ubomír Borko ◽  
Július Kostan ◽  
Alexandra Zahradníkova ◽  
Vladimír Pevala ◽  
Juraj Gasperík ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Terminal Region ◽  
X Ray ◽  
Cardiac Ryanodine Receptor

scholarly journals Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

2021 ◽  
pp. 101412
Author(s):  
Jingyan Zhang ◽  
Daniel P. Singh ◽  
Christopher Y. Ko ◽  
Roman Nikolaienko ◽  
Siobhan M. Wong King Yuen ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
High Throughput ◽  
High Throughput Screening ◽  
Terminal Region ◽  
Cardiac Ryanodine Receptor

The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

2012 ◽  
Vol 83 (11) ◽  
pp. 1523-1529 ◽  
Author(s):  
Dan Liu ◽  
Ruwani Hewawasam ◽  
Yamuna Karunasekara ◽  
Marco G. Casarotto ◽  
Angela F. Dulhunty ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Glutathione Transferase ◽  
Divergent Region ◽  
Cardiac Ryanodine Receptor

Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor

2015 ◽  
Vol 467 (1) ◽  
pp. 177-190 ◽  
Author(s):  
Tao Mi ◽  
Zhichao Xiao ◽  
Wenting Guo ◽  
Yijun Tang ◽  
Florian Hiess ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Central Region ◽  
Calcium Release ◽  
Important Determinant ◽  
Cardiac Ryanodine Receptor

Cys3602 in cardiac ryanodine receptor (RyR) mediates the action of the thiol agent N-ethylmaleimide, but not 4,4′-dithiodipyridine (DTDP). A central region encompassing the calmodulin (CaM)-binding site and Cys3602 in cardiac RyR represents an important determinant of calcium-release activation and termination.

scholarly journals The Active Site of O-Acetylserine Sulfhydrylase Is the Anchor Point for Bienzyme Complex Formation with Serine Acetyltransferase

2005 ◽  
Vol 187 (9) ◽  
pp. 3201-3205 ◽  
Author(s):  
Bin Huang ◽  
Matthew W. Vetting ◽  
Steven L. Roderick
Keyword(s):  
Crystal Structure ◽  
Complex Formation ◽  
Binding Site ◽  
Active Site ◽  
Binding Pocket ◽  
Anion Binding ◽  
Carboxyl Group ◽  
Serine Acetyltransferase ◽  
Cysteine Synthase

ABSTRACT The biosynthesis of cysteine in bacteria and plants is carried out by a two-step pathway, catalyzed by serine acetyltransferase (SAT) and O-acetylserine sulfhydrylase (OASS; O-acetylserine [thiol] lyase). The aerobic form of OASS forms a tight bienzyme complex with SAT in vivo, termed cysteine synthase. We have determined the crystal structure of OASS in complex with a C-terminal peptide of SAT required for bienzyme complex formation. The binding site of the peptide is at the active site of OASS, and its C-terminal carboxyl group occupies the same anion binding pocket as the α-carboxylate of the O-acetylserine substrate of OASS. These results explain the partial inhibition of OASS by SAT on complex formation as well as the competitive dissociation of the complex by O-acetylserine.

Sign in / Sign up

Export Citation Format

Share Document