In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals

Physiologically Based ◽

Input Parameters ◽

Liver And Kidney ◽

An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.1c00249 ◽

2021 ◽

Author(s):

Yusuke Kamiya ◽

Kentaro Handa ◽

Tomonori Miura ◽

Junya Ohori ◽

Makiko Shimizu ◽

...

Keyword(s):

In Silico ◽

Prediction Method ◽

Systemic Circulation ◽

Pharmacokinetic Models ◽

In Silico Prediction ◽

Tissue Concentrations ◽

Physiologically Based ◽

Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid

The Journal of Toxicological Sciences ◽

10.2131/jts.45.763 ◽

2020 ◽

Vol 45 (12) ◽

pp. 763-767

Author(s):

Yusuke Kamiya ◽

Mayu Yanagi ◽

Shiori Hina ◽

Kazuki Shigeta ◽

Tomonori Miura ◽

...

Keyword(s):

Sulfonic Acid ◽

Pharmacokinetic Models ◽

Industrial Chemicals ◽

Physiologically Based ◽

Liver And Kidney ◽

Physiologically Based Pharmacokinetic Models: Integration of In Silico Approaches with Micro Cell Culture Analogues

Current Drug Metabolism ◽

10.2174/138920012800840419 ◽

2012 ◽

Vol 13 (6) ◽

pp. 863-880 ◽

Cited By ~ 8

Author(s):

A. Chen ◽

M. L. Yarmush ◽

T. Maguire

Keyword(s):

Cell Culture ◽

In Silico ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats

Chemical Research in Toxicology ◽

10.1021/acs.chemrestox.0c00009 ◽

2020 ◽

Vol 33 (7) ◽

pp. 1736-1751 ◽

Cited By ~ 5

Author(s):

Yusuke Kamiya ◽

Shohei Otsuka ◽

Tomonori Miura ◽

Manae Yoshizawa ◽

Ayane Nakano ◽

...

Keyword(s):

Pharmacokinetic Models ◽

Industrial Chemicals ◽

Physiologically Based ◽

In Silico Predictions of Partition Coefficients for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-8 ◽

2016 ◽

pp. 141-183

Author(s):

Kannan Krishnan ◽

Andy Nong ◽

Sami Haddad

Keyword(s):

In Silico ◽

Partition Coefficients ◽

Pharmacokinetic Models ◽

Physiologically Based ◽

In Silico Predictions

Uncertainties in physiologically based pharmacokinetic models caused by several input parameters

International Archives of Occupational and Environmental Health ◽

10.1007/s004200050368 ◽

1999 ◽

Vol 72 (4) ◽

pp. 247-254 ◽

Cited By ~ 5

Author(s):

Jae-Yeon Jang ◽

P. O. Droz ◽

Ho Keun Chung

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based ◽

Input Parameters

Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Cited By ~ 7

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Pesticide Exposures ◽

Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Cited By ~ 5

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based ◽

In Vivo Extrapolation

Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-16 ◽

2006 ◽

pp. 301-348 ◽

Cited By ~ 2

Author(s):

Robert De Woskin ◽

Chadwick Thompson ◽

Weihsueh Chiu ◽

Paul Schlosser ◽

Carolyn Smallwood ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Integrated Risk ◽