Crossing Biological Barriers by Engineered Nanoparticles

2020 ◽  
Vol 33 (5) ◽  
pp. 1055-1060
Author(s):  
Jianbo Jia ◽  
Zengjin Wang ◽  
Tongtao Yue ◽  
Gaoxing Su ◽  
Chuanfeng Teng ◽  
...  
Keyword(s):  
Engineered Nanoparticles ◽  
Biological Barriers

Engineered nanomaterials induce alterations in biological barriers: focus on paracellular permeability

Nanomedicine ◽  
2021 ◽  
Author(s):  
Lan-Min Wang ◽  
Yu-Ting Wang ◽  
Wan-Xi Yang
Keyword(s):  
Signaling Pathways ◽  
Food Additives ◽  
Paracellular Permeability ◽  
Engineered Nanoparticles ◽  
Energy Materials ◽  
Beneficial Effects ◽  
Biological Barriers ◽  
Adhesion Junctions ◽  
Metal Metal ◽  
Metal Oxide Nanomaterials

Engineered nanoparticles (ENPs) are widely used in medical diagnosis and treatment, as food additives and as energy materials. ENPs may exert adverse or beneficial effects on the human body, which may be linked to interactions with biological barriers. In this review, the authors summarize the influences of four typical metal/metal oxide nanomaterials (Ag, TiO2, Au, ZnO nanoparticles) on the paracellular permeability of biological barriers. Disruptions on tight junctions, adhesion junctions, gap junctions and desmosomes via complex signaling pathways, such as the MAPK, PKC and ROCK signaling pathways, affect paracellular permeability. Reactive oxygen species and cytokines underlie the mechanism of ENP-triggered alterations in paracellular permeability. This review provides the information necessary for the cautious application of nanoparticles in medicine and life sciences in the future.

scholarly journals Interactions of Engineered Nanoparticles with Organs Protected by Internal Biological Barriers

Small ◽  
2012 ◽  
Vol 9 (9-10) ◽  
pp. 1557-1572 ◽  
Author(s):  
Antonio Pietroiusti ◽  
Luisa Campagnolo ◽  
Bengt Fadeel
Keyword(s):  
Engineered Nanoparticles ◽  
Biological Barriers

Review of Biological Barriers in Behavioral Medicine.

1991 ◽  
Vol 36 (7) ◽  
pp. 641-641
Author(s):  
No authorship indicated
Keyword(s):  
Behavioral Medicine ◽  
Biological Barriers

REVIEW ON RECENT ADVANCES IN ENVIRONMENTAL REMEDIATION AND RELATED TOXICITY OF ENGINEERED NANOPARTICLES

2016 ◽  
Vol 15 (4) ◽  
pp. 923-934 ◽  
Author(s):  
Mohammadreza Kamali ◽  
Ana Paula Duarte Gomes ◽  
Zahra Khodaparast ◽  
Tahereh Seifi
Keyword(s):  
Environmental Remediation ◽  
Engineered Nanoparticles ◽  
Recent Advances

Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Triple Negative ◽  
Growth Factor Receptor ◽  
Engineered Nanoparticles ◽  
Efficacy Evaluation ◽  
Dual Action ◽  
Epidermal Growth ◽  
Laminin 411 ◽  
Immunologic Analysis

Engineered nanoparticles are widely used for delivery of drugs but frequently lack proof of safetyfor cancer patient's treatment. All-in-one covalent nanodrugs of the third generation have beensynthesized based on a poly(β-L-malic acid) (PMLA) platform, targeting human triple-negativebreast cancer (TNBC). They significantly inhibited tumor growth in nude mice by blockingsynthesis of epidermal growth factor receptor, and α4 and β1 chains of laminin-411, the tumorvascular wall protein and angiogenesis marker. PMLA and nanodrug biocompatibility and toxicityat low and high dosages were evaluated in vitro and in vivo. The dual-action nanodrug and singleactionprecursor nanoconjugates were assessed under in vitro conditions and in vivo with multipletreatment regimens (6 and 12 treatments). The monitoring of TNBC treatment in vivo withdifferent drugs included blood hematologic and immunologic analysis after multiple intravenousadministrations. The present study demonstrates that the dual-action nanoconju-gate is highlyeffective in preclinical TNBC treatment without side effects, supported by hematologic andimmunologic assays data. PMLA-based nanodrugs of the Polycefin™ family passed multipletoxicity and efficacy tests in vitro and in vivo on preclinical level and may prove to be optimizedand efficacious for the treatment of cancer patients in the future.

The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery

2016 ◽  
Vol 22 (9) ◽  
pp. 1259-1273 ◽  
Author(s):  
Carolyn Jordan ◽  
Vladimir V. Shuvaev ◽  
Mark Bailey ◽  
Vladimir R. Muzykantov ◽  
Thomas D. Dziubla
Keyword(s):  
Drug Delivery ◽  
Biological Barriers

Evaluation of the Biological Fate and the Transport Through Biological Barriers of Nanosilver in Mice

2013 ◽  
Vol 19 (37) ◽  
pp. 6691-6697 ◽  
Author(s):  
Zhe Wang ◽  
Guangbo Qu ◽  
Lina Su ◽  
Lei Wang ◽  
Zuozhi Yang ◽  
...  
Keyword(s):  
Biological Barriers ◽  
Biological Fate

Engineered Nanoparticles with Antimicrobial Property

2018 ◽  
Vol 18 (11) ◽  
pp. 1040-1054 ◽  
Author(s):  
Veliyath Gopi Reshma ◽  
Santhakumar Syama ◽  
Sudhakaran Sruthi ◽  
Sebastain Cherian Reshma ◽  
Nirmal Suma Remya ◽  
...  
Keyword(s):  
Antimicrobial Property ◽  
Engineered Nanoparticles

Coating ligands mediated dynamic formation of natural organic matter (NOM) corona on engineered nanoparticles in environments

2021 ◽  
Author(s):  
Chuan-Wang Yang ◽  
Li Yuan ◽  
Hong-Zhi Zhou ◽  
Xin Zhang ◽  
Guo-Ping Sheng
Keyword(s):  
Organic Matter ◽  
Natural Organic Matter ◽  
Engineered Nanoparticles ◽  
Aquatic Systems ◽  
Solution Interface ◽  
Dynamic Formation

Natural organic matter (NOM) can adsorb onto engineered nanoparticles (ENPs) and form NOM-corona on ENPs-solution interface, thus affecting the performance and ecotoxicity of ENPs in aquatic systems. Nevertheless, the formation...

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