Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot–Marie–Tooth Type 2A Mouse Model

2021 ◽  
Vol 64 (8) ◽  
pp. 4810-4840
Author(s):  
Sida Shen ◽  
Cristina Picci ◽  
Kseniya Ustinova ◽  
Veronick Benoy ◽  
Zsófia Kutil ◽  
...  
Keyword(s):  
Mouse Model ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Charcot Marie Tooth ◽  
Tooth Type

scholarly journals Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot–Marie–Tooth type 1B mouse model

2018 ◽  
Vol 28 (6) ◽  
pp. 992-1006 ◽  
Author(s):  
Cristina Scapin ◽  
Cinzia Ferri ◽  
Emanuela Pettinato ◽  
Desiree Zambroni ◽  
Francesca Bianchi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Neuregulin 1 ◽  
Charcot Marie Tooth ◽  
Type Iii ◽  
Tooth Type

scholarly journals Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot–Marie–Tooth type 2A

2007 ◽  
Vol 17 (3) ◽  
pp. 367-375 ◽  
Author(s):  
Scott A. Detmer ◽  
Christine Vande Velde ◽  
Don W. Cleveland ◽  
David C. Chan
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Motor Axon ◽  
Charcot Marie Tooth ◽  
Axon Loss ◽  
Tooth Type

scholarly journals Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot–Marie–Tooth Disease

2015 ◽  
Vol 7 (2) ◽  
pp. 240-258 ◽  
Author(s):  
Sida Shen ◽  
Veronick Benoy ◽  
Joel A. Bergman ◽  
Jay H. Kalin ◽  
Mariana Frojuello ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Charcot Marie Tooth ◽  
Charcot Marie Tooth Disease ◽  
Tooth Disease

scholarly journals Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

2014 ◽  
Vol 6 (1) ◽  
pp. 12 ◽  
Author(s):  
Maj-Linda Selenica ◽  
Leif Benner ◽  
Steven B Housley ◽  
Barbara Manchec ◽  
Daniel C Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Total Tau

scholarly journals Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome

2018 ◽  
Vol 10 (3) ◽  
pp. 1679-1695 ◽  
Author(s):  
Alan P. Kozikowski ◽  
Sida Shen ◽  
Marta Pardo ◽  
Maurício T. Tavares ◽  
Dora Szarics ◽  
...  
Keyword(s):  
Mouse Model ◽  
Fragile X Syndrome ◽  
Histone Deacetylase ◽  
Fragile X ◽  
Histone Deacetylase 6 ◽  
Memory And Learning ◽  
Learning Impairments

scholarly journals Metabolite profile of a mouse model of Charcot–Marie–Tooth type 2D neuropathy: implications for disease mechanisms and interventions

Biology Open ◽  
2016 ◽  
Vol 5 (7) ◽  
pp. 908-920 ◽  
Author(s):  
Preeti Bais ◽  
Kirk Beebe ◽  
Kathryn H. Morelli ◽  
Meagan E. Currie ◽  
Sara N. Norberg ◽  
...  
Keyword(s):  
Mouse Model ◽  
Metabolite Profile ◽  
Charcot Marie Tooth ◽  
Disease Mechanisms ◽  
Tooth Type

scholarly journals A novel mouse model carrying a human cytoplasmic dynein mutation shows motor behavior deficits consistent with Charcot-Marie-Tooth type 2O disease

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Thywill T. Sabblah ◽  
Swaran Nandini ◽  
Aaron P. Ledray ◽  
Julio Pasos ◽  
Jami L. Conley Calderon ◽  
...  
Keyword(s):  
Mouse Model ◽  
Motor Behavior ◽  
Cytoplasmic Dynein ◽  
Charcot Marie Tooth ◽  
Tooth Type
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