Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00417 ◽

2021 ◽

Author(s):

Mónica García ◽

Virginia Llorente ◽

Lourdes Garriga ◽

Ute Christmann ◽

Sergi Rodríguez-Escrich ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Σ1 Receptor ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.9b01256 ◽

2019 ◽

Vol 63 (5) ◽

pp. 2434-2454 ◽

Author(s):

Mónica García ◽

Marina Virgili ◽

Mònica Alonso ◽

Carles Alegret ◽

Begoña Fernández ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Σ1 Receptor ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Transformation of μ-opioid receptor agonists into biologically potent μ-opioid receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.11.019 ◽

2007 ◽

Vol 15 (3) ◽

pp. 1237-1251 ◽

Author(s):

Tingyou Li ◽

Yunden Jinsmaa ◽

Masahiro Nedachi ◽

Anna Miyazaki ◽

Yuko Tsuda ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Opioid Receptor Antagonists ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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The Importance of Micelle-Bound States for the Bioactivities of Bifunctional Peptide Derivatives for δ/μ Opioid Receptor Agonists and Neurokinin 1 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm800389v ◽

2008 ◽

Vol 51 (20) ◽

pp. 6334-6347 ◽

Author(s):

Takashi Yamamoto ◽

Padma Nair ◽

Neil E. Jacobsen ◽

Peg Davis ◽

Shou-wu Ma ◽

...

Keyword(s):

Opioid Receptor ◽

Bound States ◽

Receptor Antagonists ◽

Neurokinin 1 Receptor ◽

Receptor Agonists ◽

Peptide Derivatives ◽

Μ Opioid Receptor ◽

Neurokinin 1 ◽

Opioid Receptor Agonists

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Design and Synthesis of Novel Hydrazide-Linked Bifunctional Peptides as δ/μ Opioid Receptor Agonists and CCK-1/CCK-2 Receptor Antagonists

Journal of Medicinal Chemistry ◽

10.1021/jm050851n ◽

2006 ◽

Vol 49 (5) ◽

pp. 1773-1780 ◽

Author(s):

Yeon Sun Lee ◽

Richard S. Agnes ◽

Hamid Badghisi ◽

Peg Davis ◽

Shou-wu Ma ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Design And Synthesis ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences ◽

10.1254/jphs.scj05006x ◽

2006 ◽

Vol 100 (2) ◽

pp. 157-161 ◽

Author(s):

Tomohisa Mori ◽

Mutsuko Nomura ◽

Kazumi Yoshizawa ◽

Hiroshi Nagase ◽

Toshiko Sawaguchi ◽

...

Keyword(s):

Nmda Receptor ◽

Opioid Receptor ◽

Discriminative Stimulus ◽

Nmda Receptor Antagonists ◽

Receptor Antagonists ◽

Receptor Agonists ◽

Discriminative Stimulus Effects ◽

Stimulus Effects ◽

Opioid Receptor Agonists

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Mechanisms Responsible for the Enhanced Antinociceptive Effects of μ-Opioid Receptor Agonists in the Rostral Ventromedial Medulla of Male Rats with Persistent Inflammatory Pain

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.121954 ◽

2007 ◽

Vol 322 (2) ◽

pp. 813-821 ◽

Author(s):

Kenneth T. Sykes ◽

Stephanie R. White ◽

Robert W. Hurley ◽

Hirokazu Mizoguchi ◽

Leon F. Tseng ◽

...

Keyword(s):

Opioid Receptor ◽

Inflammatory Pain ◽

Male Rats ◽

Rostral Ventromedial Medulla ◽

Receptor Agonists ◽

Antinociceptive Effects ◽

Ventromedial Medulla ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Control of 4-aminopyridine-induced synchronous activity by adenosine A1 and μ-opioid receptor agonists in adult rat hippocampus

Neuroscience Letters ◽

10.1016/0304-3940(94)90799-4 ◽

1994 ◽

Vol 182 (2) ◽

pp. 208-212 ◽

Author(s):

M.T. Barbarosie ◽

T. Nagao ◽

M. Avoli

Keyword(s):

Opioid Receptor ◽

Rat Hippocampus ◽

Synchronous Activity ◽

Receptor Agonists ◽

Adult Rat ◽

Adenosine A1 ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Contribution of Endogenous Enkephalins to the Enhanced Analgesic Effects of Supraspinal μ Opioid Receptor Agonists after Inflammatory Injury

Journal of Neuroscience ◽

10.1523/jneurosci.21-07-02536.2001 ◽

2001 ◽

Vol 21 (7) ◽

pp. 2536-2545 ◽

Author(s):

Robert W. Hurley ◽

Donna L. Hammond

Keyword(s):

Opioid Receptor ◽

Inflammatory Injury ◽

Receptor Agonists ◽

Analgesic Effects ◽

Endogenous Enkephalins ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Neurons in the Rat Arcuate Nucleus Are Hyperpolarized by GABAB and μ-Opioid Receptor Agonists: Evidence for Convergence at a Ligand-Gated Potassium Conductance

Neuroendocrinology ◽

10.1159/000125979 ◽

1991 ◽

Vol 54 (6) ◽

pp. 537-544 ◽

Author(s):

Michael D. Loose ◽

Oline K. Ronnekleiv ◽

Martin J. Kelly

Keyword(s):

Opioid Receptor ◽

Arcuate Nucleus ◽

Potassium Conductance ◽

Receptor Agonists ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00487 ◽

2020 ◽

Author(s):

Huoming Huang ◽

Xinwei Li ◽

Wei Guo ◽

Chen Zhu ◽

Yuanyuan Qian ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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