Structure–Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities

2015 ◽  
Vol 58 (12) ◽  
pp. 5108-5120 ◽  
Author(s):  
Girish Chandra ◽  
Yang Won Moon ◽  
Yoonji Lee ◽  
Ji Yong Jang ◽  
Jayoung Song ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Adenosylhomocysteine Hydrolase ◽  
Structure Activity Relationships ◽  
Neplanocin A ◽  
Structure Activity

Bis-coumarin Derivatives and Their Biological Activities

2018 ◽  
Vol 18 (2) ◽  
pp. 101-113 ◽  
Author(s):  
Qing-Cheng Ren ◽  
Chuan Gao ◽  
Zhi Xu ◽  
Lian-Shun Feng ◽  
Ming-Liang Liu ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Active Sites ◽  
Noncovalent Interactions ◽  
Biological Activities ◽  
Coumarin Derivatives ◽  
Antitumor Activities ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Biological Potential

Bis-coumarins have caused great interests in the recent years. These compounds exhibit diverse biological activities which are ascribed to their ability to exert noncovalent interactions with the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous biscoumarin derivatives have been synthesized and screened for their biological activities, and many of them showed promising potency. This review is focused on the biological potential of bis-coumarin derivatives with particular mention of those exhibiting antibacterial, anticoagulant, antiinflammatory, antiviral, anti-parasite and antitumor activities, and their structure-activity relationships are also discussed.

scholarly journals Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 479 ◽  
Author(s):  
Rawda Okasha ◽  
Fawzia Alblewi ◽  
Tarek Afifi ◽  
Arshi Naqvi ◽  
Ahmed Fouda ◽  
...  
Keyword(s):  
Antitumor Activities ◽  
Structure Activity Relationships ◽  
Structure Activity
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