Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis

2019 ◽  
Vol 62 (19) ◽  
pp. 8796-8808 ◽  
Author(s):  
Niall A. Anderson ◽  
Sebastien Campos ◽  
Sharon Butler ◽  
Royston C. B. Copley ◽  
Ian Duncan ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Orally Bioavailable ◽  
Integrin Inhibitor

Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis

2016 ◽  
Vol 14 (25) ◽  
pp. 5992-6009 ◽  
Author(s):  
Niall A. Anderson ◽  
Ian B. Campbell ◽  
Brendan J. Fallon ◽  
Sean M. Lynn ◽  
Simon J. F. Macdonald ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Absolute Configuration ◽  
Determination Of Absolute Configuration ◽  
Αvβ6 Integrin ◽  
Integrin Inhibitor ◽  
Adhesion Assays

Integrin inhibitor (cell adhesion assays) pIC50 αvβ6 = 8.4, αvβ3 = 6.0, αvβ5 = 5.9 and αvβ8 = 7.7.

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

2010 ◽  
Vol 53 (21) ◽  
pp. 7715-7730 ◽  
Author(s):  
Benoı̂t Laleu ◽  
Francesca Gaggini ◽  
Mike Orchard ◽  
Laetitia Fioraso-Cartier ◽  
Laurène Cagnon ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Nadph Oxidase ◽  
Orally Bioavailable

Role of Wnt/PCP pathway on bronchial cell function in Idiopathic Pulmonary Fibrosis

Pneumologie ◽  
2011 ◽  
Vol 65 (12) ◽  
Author(s):  
S Barkha ◽  
M Gegg ◽  
H Lickert ◽  
M Königshoff
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cell Function

Regulation of Macroautophagy in Idiopathic Pulmonary Fibrosis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
P Mahavadi ◽  
S Ahuja ◽  
I Henneke ◽  
W Klepetko ◽  
C Ruppert ◽  
...  
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth
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