ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum

The aerial parts of Salvia cinnabarina afforded two undescribed labdane diterpenoids 1 and 2 (malonylcommunol and 6β-hydroxy-trans-communic acid) along with two known labdane diterpenoids, trans-communic acid (3) and trans-communol (4). Additionally, seven known metabolites were also isolated; two isopimarane diterpenoids 5 and 6, two sesquiterpenoids identified as β-eudesmol (7) and cryptomeridiol (8), and three aromatic compounds identified as phthalic acid (9), a mixture of tyrosol fatty acid esters (10) and the flavone salvigenine (11). While compounds compounds 1–3 showed significant inhibition of yeast α-glucosidase, compounds 2, 3 and 7 had no anti-inflammatory activity in the edema model induced by TPA. This paper is not only the first report on a wild population of Salvia cinnabarina, but also of the presence of labdane-type diterpenoids in a Mexican Salvia sp.

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Three labdane diterpenoids from the aerial parts of Leonurus japonicus

Phytochemistry Letters ◽

10.1016/j.phytol.2021.06.003 ◽

2021 ◽

Vol 44 ◽

pp. 82-86

Author(s):

Ly T.T. Nguyen ◽

Phuong T. Tran ◽

Dzung N. Bui ◽

Hieu T. Nguyen ◽

Binh T.D. Trinh ◽

...

Keyword(s):

Aerial Parts ◽

Labdane Diterpenoids

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Nine Newent-Labdane Diterpenoids from the Aerial Parts ofAndrographis paniculata

Helvetica Chimica Acta ◽

10.1002/hlca.200690237 ◽

2006 ◽

Vol 89 (11) ◽

pp. 2654-2664 ◽

Cited By ~ 31

Author(s):

Li-Xia Chen ◽

Feng Qiu ◽

Hong Wei ◽

Ge-Xia Qu ◽

Xin-Sheng Yao

Keyword(s):

Aerial Parts ◽

Labdane Diterpenoids

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Identification of new labdane diterpenoids from the aerial parts of Otostegia persica utilizing NMR and circular dichroism calculations

10.1055/s-0039-3399887 ◽

2019 ◽

Author(s):

M Alilou ◽

S Schwaiger ◽

H Stuppner

Keyword(s):

Circular Dichroism ◽

Aerial Parts ◽

Otostegia Persica ◽

Labdane Diterpenoids ◽

Circular Dichroïsm

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Bioactive-guided Identification of Labdane Diterpenoids from Aerial Parts of Aristeguietia glutinosa as anti-Trypanosoma cruzi agents

Natural Product Communications ◽

10.1177/1934578x1200700907 ◽

2012 ◽

Vol 7 (9) ◽

pp. 1934578X1200700 ◽

Cited By ~ 1

Author(s):

Javier Varela ◽

María L. Lavaggi ◽

Mauricio Cabrera ◽

Alejandra Rodríguez ◽

Patricio Miño ◽

...

Keyword(s):

Trypanosoma Cruzi ◽

Hemolytic Activity ◽

Spectroscopic Analysis ◽

Ethanolic Extract ◽

Reference Compound ◽

Murine Macrophages ◽

Aerial Parts ◽

Medicinal Use ◽

Low Toxicity ◽

Labdane Diterpenoids

A bioactive-guided investigation of the hydro-ethanolic extract of aerial parts of Aristeguietia glutinosa Lam. resulted in the isolation of two diterpenoids, (+)-15-hydroxy-labd-7-en-17-al (1) and (+)-13,14,15,16-tetranor-labd-7-en-l7,12-olide (2), as the anti- Trypanosoma cruzi active principles. The structures of 1 and 2 were determined by spectroscopic analysis. The hydro-ethanolic extract showed anti- T. cruzi activity (IC50= 19.6 μg/mL) whereas the isolated compounds 1 and 2 were near to seven- and one and a half-fold (IC50= 3.0 and 15.6 μg/mL), respectively more active than the original extract. Labdene 1, equipotent as the reference compound (Nifurtimox), displayed low hemolytic activity, low toxicity against murine macrophages, and absence of mutagenicity. These results support the vernacular medicinal use of this plant as an anti- T. cruzi agent.

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