Acid-Catalyzed Synthesis of Isatoic Anhydride-8-Secondary Amides Enables IASA Transformations for Medicinal Chemistry

2021 ◽  
Author(s):  
Sudershan R. Gondi ◽  
Althaf Shaik ◽  
Kenneth D. Westover
Keyword(s):  
Medicinal Chemistry ◽  
Isatoic Anhydride ◽  
Acid Catalyzed ◽  
Secondary Amides

scholarly journals Formation of 1,2,3-Triazoles, Secondary Amides, alpha-Aminoketones, and Vinylketones in the Acid-catalyzed Decomposition of 5-Hydroxy-Delta2-1,2,3-Triazolines.

1975 ◽  
Vol 29b ◽  
pp. 953-962 ◽  
Author(s):  
Carl Erik Olsen ◽  
Majken Elander ◽  
Lars Manhem ◽  
Gunner Borch ◽  
Synnøve Liaaen-Jensen
Keyword(s):  
Acid Catalyzed ◽  
Secondary Amides

scholarly journals Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds

2021 ◽  
Vol 17 ◽  
pp. 2729-2764
Author(s):  
Alemayehu Gashaw Woldegiorgis ◽  
Xufeng Lin
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Medicinal Chemistry ◽  
High Efficiency ◽  
Biologically Active ◽  
Chiral Compounds ◽  
Chiral Phosphoric Acid ◽  
Wide Range ◽  
Axially Chiral ◽  
Acid Catalyzed

In recent years, the synthesis of axially chiral compounds has received considerable attention due to their extensive application as biologically active compounds in medicinal chemistry and as chiral ligands in asymmetric catalysis. Chiral phosphoric acids are recognized as efficient organocatalysts for a variety of enantioselective transformations. In this review, we summarize the recent development of chiral phosphoric acid-catalyzed synthesis of a wide range of axially chiral biaryls, heterobiaryls, vinylarenes, N-arylamines, spiranes, and allenes with high efficiency and excellent stereoselectivity.

scholarly journals Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers

Synthesis ◽  
2017 ◽  
Vol 49 (18) ◽  
pp. 4229-4246 ◽  
Author(s):  
Arun Ghosh ◽  
Anthony Tomaine ◽  
Kelsey Cantwell
Keyword(s):  
Natural Products ◽  
Drug Design ◽  
Lewis Acid ◽  
Medicinal Chemistry ◽  
Cyclic Ether ◽  
Cyclic Ethers ◽  
Diastereoselective Synthesis ◽  
Acid Catalyzed

Cyclic ethers are widely abundant in natural products. Cyclic ether templates are also utilized in drug design and medicinal chemistry. Although the synthetic processes for this class of compounds have been studied extensively with respect to five- and six-membered rings, medium-sized cyclic ethers are synthetically more challenging due to a variety of factors. Herein, we report our results on the Lewis acid catalyzed synthesis of medium-sized cyclic ethers in a diastereoselective manner.

NMR site-to-site rate constants and the mechanisms of acid-catalyzed proton exchange in secondary amides

1984 ◽  
Vol 106 (10) ◽  
pp. 2749-2753 ◽  
Author(s):  
Charles L. Perrin ◽  
Charles Peter Lollo ◽  
Eric R. Johnston
Keyword(s):  
Rate Constants ◽  
Proton Exchange ◽  
Acid Catalyzed ◽  
Secondary Amides

Acid Catalyzed Furan Ring Transposition

10.1039/sp768 ◽  
2014 ◽  
Author(s):  
Jamsheena V. ◽  
Ravindra Phatake
Keyword(s):  
Furan Ring ◽  
Acid Catalyzed
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