Mechanism of Amide Bond Formation from Carboxylic Acids and Amines Promoted by 9-Silafluorenyl Dichloride Derivatives

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

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Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

Organic & Biomolecular Chemistry ◽

10.1039/c7ob01510k ◽

2017 ◽

Vol 15 (30) ◽

pp. 6426-6432 ◽

Cited By ~ 12

Author(s):

Daan F. J. Hamstra ◽

Danny C. Lenstra ◽

Tjeu J. Koenders ◽

Floris P. J. T. Rutjes ◽

Jasmin Mecinović

Keyword(s):

Carboxylic Acids ◽

Phosphine Oxide ◽

Bond Formation ◽

Reducing Agent ◽

Amide Bond ◽

Amide Bond Formation ◽

Amidation Reaction

In situ reduction of phosphine oxide by poly(methylhydrosiloxane) leads to efficient amidation reaction between carboxylic acids and amines.

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Efficient Amide Bond Formation through a Rapid and Strong Activation of Carboxylic Acids in a Microflow Reactor

Angewandte Chemie ◽

10.1002/ange.201307987 ◽

2013 ◽

Vol 126 (3) ◽

pp. 870-874 ◽

Cited By ~ 29

Author(s):

Shinichiro Fuse ◽

Yuto Mifune ◽

Takashi Takahashi

Keyword(s):

Carboxylic Acids ◽

Bond Formation ◽

Amide Bond ◽

Amide Bond Formation ◽

Microflow Reactor

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ChemInform Abstract: Solvent-Free Protocol for Amide Bond Formation via Trapping of Nascent Phosphazenes with Carboxylic Acids.

ChemInform ◽

10.1002/chin.201137051 ◽

2011 ◽

Vol 42 (37) ◽

pp. no-no

Author(s):

Murugan Sathishkumar ◽

Poovan Shanmugavelan ◽

Sangaraiah Nagarajan ◽

Murugesan Maheswari ◽

Murugan Dinesh ◽

...

Keyword(s):

Carboxylic Acids ◽

Bond Formation ◽

Solvent Free ◽

Amide Bond ◽

Amide Bond Formation

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Cu(II)–acetylacetone complex covalently anchored onto magnetic nanoparticles: Synthesis, characterization and catalytic evaluation in amide bond formation via oxidative coupling of carboxylic acids with N,N-dialkylformamides

Journal of Organometallic Chemistry ◽

10.1016/j.jorganchem.2014.09.024 ◽

2014 ◽

Vol 772-773 ◽

pp. 222-228 ◽

Cited By ~ 28

Author(s):

Dariush Saberi ◽

Samaneh Mahdudi ◽

Samaneh Cheraghi ◽

Akbar Heydari

Keyword(s):

Magnetic Nanoparticles ◽

Carboxylic Acids ◽

Oxidative Coupling ◽

Bond Formation ◽

Amide Bond ◽

Amide Bond Formation ◽

Nanoparticles Synthesis

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Diphenylsilane as a coupling reagent for amide bond formation

Green Chemistry ◽

10.1039/c7gc02643a ◽

2017 ◽

Vol 19 (21) ◽

pp. 5060-5064 ◽

Cited By ~ 24

Author(s):

Morgane Sayes ◽

André B. Charette

Keyword(s):

Carboxylic Acids ◽

Bond Formation ◽

Direct Coupling ◽

Amide Bond ◽

Amide Bond Formation ◽

Coupling Reagent

A simple amidation procedure enabling the direct coupling of carboxylic acids to amines using one equivalent of diphenysilane is reported.

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Fast TiO2-catalyzed direct amidation of neat carboxylic acids under mild dielectric heating

Catalysis Science & Technology ◽

10.1039/c4cy00038b ◽

2014 ◽

Vol 4 (5) ◽

pp. 1395-1399 ◽

Cited By ~ 12

Author(s):

E. Calcio Gaudino ◽

D. Carnaroglio ◽

M. A. G. Nunes ◽

L. Schmidt ◽

E. M. M. Flores ◽

...

Keyword(s):

Carboxylic Acids ◽

Bond Formation ◽

Academic Research ◽

Amide Bond ◽

Dielectric Heating ◽

Amide Bond Formation ◽

Important Challenge ◽

Pharmaceutical Industries ◽

Direct Amidation

The development of green protocols for amide bond formation is a major socioeconomic goal for chemical and pharmaceutical industries and an important challenge for academic research.

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