Quantum Mechanical Enhancement of Rate Constants and Kinetic Isotope Effects for Water-Mediated Proton Transfer in a Model Biological System

2017 ◽  
Vol 121 (4) ◽  
pp. 819-826 ◽  
Author(s):  
James W. Mazzuca ◽  
Chase P. Schultz
Keyword(s):  
Proton Transfer ◽  
Biological System ◽  
Rate Constants ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Quantum Mechanical ◽  
Kinetic Isotope

scholarly journals Heavy-Enzyme Kinetic Isotope Effects on Proton Transfer in Alanine Racemase

2013 ◽  
Vol 135 (7) ◽  
pp. 2509-2511 ◽  
Author(s):  
Michael D. Toney ◽  
Joan Nieto Castro ◽  
Trevor A. Addington
Keyword(s):  
Proton Transfer ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Alanine Racemase ◽  
Enzyme Kinetic ◽  
Kinetic Isotope

A Theoretical Analysis of Rate Constants and Kinetic Isotope Effects Corresponding to Different Reactant Valleys in Lactate Dehydrogenase

2006 ◽  
Vol 128 (51) ◽  
pp. 16851-16863 ◽  
Author(s):  
Silvia Ferrer ◽  
Iñaki Tuñón ◽  
Sergio Martí ◽  
Vicente Moliner ◽  
Mireia Garcia-Viloca ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Theoretical Analysis ◽  
Rate Constants ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope

Kinetic Isotope Effects in Multiple Proton Transfer

2005 ◽  
pp. 521-548 ◽  
Author(s):  
Willem Siebrand ◽  
Zorka Smedarchina ◽  
Antonio Fernández-Ramos
Keyword(s):  
Proton Transfer ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope
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