In Vitro and In Vivo Behaviors of KinetiSol and Spray-Dried Amorphous Solid Dispersions of a Weakly Basic Drug and Ionic Polymer

2020 ◽  
Vol 17 (8) ◽  
pp. 2789-2808 ◽  
Author(s):  
Scott V. Jermain ◽  
Michael B. Lowinger ◽  
Daniel J. Ellenberger ◽  
Dave A. Miller ◽  
Yongchao Su ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
Basic Drug ◽  
Ionic Polymer ◽  
Spray Dried

scholarly journals In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound

2013 ◽  
Vol 15 (2) ◽  
pp. 608-617 ◽  
Author(s):  
Po-Chang Chiang ◽  
Yong Cui ◽  
Yingqing Ran ◽  
Joe Lubach ◽  
Kang-Jye Chou ◽  
...  
Keyword(s):  
Model Compound ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions ◽  
In Vivo Evaluation ◽  
Bench Scale

Solvent-Casted Films to Assist Polymer Selection for Amorphous Solid Dispersions During Preclinical Studies: In-vitro and In-vivo Exploration

2021 ◽  
Author(s):  
Laura I. Mosquera-Giraldo ◽  
Maria Donoso ◽  
Kevin Stefanski ◽  
Kimberly Foster ◽  
Christoph Gesenberg ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Preclinical Studies ◽  
Amorphous Solid Dispersions ◽  
Selection For

scholarly journals Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions

2016 ◽  
Vol 18 (2) ◽  
pp. 416-423 ◽  
Author(s):  
Matthias Manne Knopp ◽  
Julia Hoang Nguyen ◽  
Huiling Mu ◽  
Peter Langguth ◽  
Thomas Rades ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Copolymer Composition ◽  
Amorphous Solid Dispersions

Predicting in vivo performance of fenofibrate amorphous solid dispersions using in vitro non-sink dissolution and dissolution permeation setup

2021 ◽  
pp. 121174
Author(s):  
Karoline Aagaard Lentz ◽  
Jakob Plum ◽  
Bente Steffansen ◽  
Per-Ola Arvidsson ◽  
Diana Højmark Omkvist ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersions

scholarly journals Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1307
Author(s):  
Yongjun Li ◽  
Amanda K. P. Mann ◽  
Dan Zhang ◽  
Zhen Yang
Keyword(s):  
Spray Drying ◽  
Solid Dispersions ◽  
Amorphous Solid ◽  
Hot Melt Extrusion ◽  
Drug Solubility ◽  
Melt Extrusion ◽  
Amorphous Solid Dispersions ◽  
Hot Melt

Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD), which convert a crystalline drug into an amorphous mixture of drug and polymer, have been demonstrated to be an effective tool in enhancing drug solubility and bioavailability. There are multiple ways to produce amorphous solid dispersions. The goal of the present study is to investigate two commonly used processing methods, hot-melt extrusion (HME) and spray drying, and their impact on drug bioperformance. The amorphous solid dispersions of a model compound, posaconazole (25% drug loading) in HPMCAS-MF, were successfully manufactured via the two processing routes, and the physicochemical properties, in vitro and in vivo performance of the resulting ASDs were characterized and compared. It was found that in vitro drug release of the ASDs from two-stage dissolution was significantly different. However, the two ASDs showed similar in vivo performance based on cynomolgus monkey PK studies. A mechanistic understanding of the in vitro and in vivo behaviors of the solid dispersions was discussed.

Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions

2016 ◽  
Vol 105 ◽  
pp. 106-114 ◽  
Author(s):  
Matthias Manne Knopp ◽  
Nabil Chourak ◽  
Fauzan Khan ◽  
Johan Wendelboe ◽  
Peter Langguth ◽  
...  
Keyword(s):  
Solid Dispersions ◽  
Amorphous Solid ◽  
Drug Dose ◽  
Amorphous Solid Dispersions ◽  
Polymer Type
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