Nickel-Catalyzed Asymmetric Transfer Hydrogenation and α-Selective Deuteration of N-Sulfonyl Imines with Alcohols: Access to α-Deuterated Chiral Amines

2020 ◽  
Vol 22 (21) ◽  
pp. 8278-8284
Author(s):  
Peng Yang ◽  
Li Zhang ◽  
Kaiyue Fu ◽  
Yaxin Sun ◽  
Xiuhua Wang ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Chiral Amines ◽  
Asymmetric Transfer Hydrogenation ◽  
Selective Deuteration

scholarly journals Design of Iridium N-Heterocyclic Carbene Amino Acid Catalysts for Asymmetric Transfer Hydrogenation of Aryl Ketones

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 671
Author(s):  
Chad M. Bernier ◽  
Joseph S. Merola
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Enantiomeric Excess ◽  
Transfer Hydrogenation ◽  
Acid Catalysts ◽  
Asymmetric Transfer Hydrogenation ◽  
Reaction Conditions ◽  
Chiral Complexes ◽  
Acetophenone Derivatives ◽  
Aryl Ketones

A series of chiral complexes of the form Ir(NHC)2(aa)(H)(X) (NHC = N-heterocyclic carbene, aa = chelated amino acid, X = halide) was synthesized by oxidative addition of -amino acids to iridium(I) bis-NHC compounds and screened for asymmetric transfer hydrogenation of ketones. Following optimization of the reaction conditions, NHC, and amino acid ligands, high enantioselectivity was achieved when employing the Ir(IMe)2(l-Pro)(H)(I) catalyst (IMe = 1,3-dimethylimidazol-2-ylidene), which asymmetrically reduces a range of acetophenone derivatives in up to 95% enantiomeric excess.

Enantioselectivity in the Noyori–Ikariya Asymmetric Transfer Hydrogenation of Ketones

2021 ◽  
Author(s):  
Pavel A. Dub ◽  
Nikolay V. Tkachenko ◽  
Vijyesh K. Vyas ◽  
Martin Wills ◽  
Justin S. Smith ◽  
...  
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

Dendritic catalysts for asymmetric transfer hydrogenation based (1S,2R)-norephedrine derived ligands

2003 ◽  
Vol 14 (16) ◽  
pp. 2481-2485 ◽  
Author(s):  
Pei Nian Liu ◽  
Ying Chun Chen ◽  
Xue Qiang Li ◽  
Yong Qiang Tu ◽  
Jin Gen Deng
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation

An Efficient Ir(III) Catalyst for the Asymmetric Transfer Hydrogenation of Ketones in Neat Water

Synlett ◽  
2006 ◽  
Vol 2006 (08) ◽  
pp. 1155-1160 ◽  
Author(s):  
Jianliang Xiao ◽  
Xiaohong Li ◽  
John Blacker ◽  
Ian Houson ◽  
Xiaofeng Wu
Keyword(s):  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Neat Water
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