Synthesis of unsymmetrical diarylacetylenes via one-pot Sonogashira/Deacetonation/Sonogashira cross-coupling of two different aryl chlorides with 2-methyl-3-butyn-2-ol was developed.
With the readily available Gorlos-Phos as a ligand, unsymmetrical biaryls were prepared efficiently from Pd-catalyzed one-pot two-step cross-coupling of two different aryl chlorides in the presence of B2Pin2.