Robust and Antiswelling Hollow Hydrogel Tube with Antibacterial and Antithrombotic Ability for Emergency Vascular Replacement

Cardiovascular diseases present amongst the highest mortality risks in Western civilization and are frequently caused by arteriosclerotic vessel failure.

Download Full-text

Autogenous Fresh and “Matured” Fascia as a Vascular Replacement

Annals of Surgery ◽

10.1097/00000658-196707000-00012 ◽

1967 ◽

Vol 166 (1) ◽

pp. 95-101 ◽

Cited By ~ 6

Author(s):

DONLEY G. MCREYNOLDS ◽

JAMES T. ADAMS ◽

JAMES A. DEWEESE

Keyword(s):

Vascular Replacement

Download Full-text

Collagen-Silk Fibroin Fibers: A Promising Scaffold for Vascular Tissue Engineering

Materials Science Forum ◽

10.4028/www.scientific.net/msf.706-709.572 ◽

2012 ◽

Vol 706-709 ◽

pp. 572-577

Author(s):

Estelle Paternotte ◽

Mariana Agostini de Moraes ◽

Marisa Masumi Beppu ◽

D. Mantovani

Keyword(s):

Tissue Engineering ◽

Silk Fibroin ◽

Vascular Tissue ◽

Small Diameter ◽

Vascular Tissue Engineering ◽

Research Teams ◽

Cellular Attachment ◽

New Models ◽

Vascular Engineering ◽

Vascular Replacement

Small caliber vascular replacement (<4 mm) still remains a challenge for medical and research teams, as no available vascular substitutes (VS) are suitable for small diameter bypass. Vascular engineering proposes new models of small diameter VS but rare are those that meet the biocompatibility and mechanical criteria. In this study, we developed a new scaffold made by the combination of two natural biomacromolecules: collagen and silk fibroin. The scaffold was further cellularised with porcine smooth muscle cells. First, the behavior of cells in the collagen-fibroin constructs was verified in order to evaluate the biocompatibility of the scaffold with the cells. Then, gel mass loss and cellular attachment, morphology, spreading and viability were analysed. The results showed an excellent interaction and biocompatibility between collagen, silk fibroin fibers and cells. Thus, the collagen-fibroin construct appears to be a very attractive material for vascular tissue engineering.

Download Full-text

Experimental results and clinical impact of using autologous rectus fascia sheath for vascular replacement

Acta Veterinaria Hungarica ◽

10.1556/avet.56.2008.3.14 ◽

2008 ◽

Vol 56 (3) ◽

pp. 411-420 ◽

Cited By ~ 4

Author(s):

László Kóbori ◽

Tibor Németh ◽

Péter Nagy ◽

Gábor Dallos ◽

Péter Sótonyi ◽

...

Keyword(s):

Patency Rate ◽

Graft Failure ◽

Histological Analysis ◽

Vascular Grafts ◽

Vascular Complications ◽

Clinical Impact ◽

Clinical Use ◽

Rectus Fascia ◽

Vascular Replacement

Vascular complications are major causes of graft failure in liver transplantation. The use of different vascular grafts is common but the results are controversial. The aim of this study was to create an ‘ideal’ arterial interponate for vascular replacements in the clinical field. An autologous, tubular graft prepared from the posterior rectus fascia sheath was used for iliac artery replacement in dogs for 1, 3, 6 and 12 months. Forty-one grafts were implanted and immunosuppression was used in separate groups. The patency rate was followed by Doppler ultrasound. Thirty-seven grafts remained patent, 2 cases with thrombosis and 2 cases with stenosis occurred. There was no evidence of necrosis or aneurysmatic formation. The histological analysis included conventional light microscopic and immunohistochemical examinations for CD34 and factor VIII. The explanted grafts showed signs of arterialisation, appearance of elastin fibres, and smooth muscle cells after 6 months. Electron microscopy showed intact mitochondrial structures without signs of hypoxia. In conclusion, the autologous graft presents acceptable long-term patency rate. It is easy to handle and the concept of beneficial presence of the anti-clot mesothelium until endothelialisation seems to work. The first clinical use was already reported by our group with more than 2 years survival.

Download Full-text

USE OF A CADAVERIC DONOR AORTA FOR VASCULAR REPLACEMENT IN KIDNEY TRANSPLANTATION

The Journal of Urology ◽

10.1016/s0022-5347(01)61803-2 ◽

1999 ◽

Vol 161 (3) ◽

pp. 909-910

Author(s):

STUART M. FLECHNER ◽

KHALED HAFEZ

Keyword(s):

Kidney Transplantation ◽

Cadaveric Donor ◽

Vascular Replacement

Download Full-text

Preliminary Design Considerations and Feasibility of a Biomimicking Tissue-Engineered Vascular Graft

10.1115/imece2000-2540 ◽

2000 ◽

Author(s):

Joel D. Stitzel ◽

Gary L. Bowlin

Keyword(s):

Vascular Graft ◽

Large Diameter ◽

Small Diameter ◽

Preliminary Design ◽

Bypass Grafts ◽

Thrombotic Occlusion ◽

Design Considerations ◽

Blood Flow Velocities ◽

Vascular Replacement ◽

Compliance Mismatch

Abstract Development of an ideal vascular replacement has been addressed with increasing urgency in recent years. To date, appropriate replacements for only large diameter bypass grafts have been realized, employing the use of Dacron and expanded polytetrafluoroethylene. A solution for small diameter (<6 mm I.D.) vessel bypass, however, has not yet been found. This is due mainly to acute thrombotic occlusion and chronic anastomotic hyperplasia that is introduced into these grafts due to the low blood flow velocities experienced by smaller caliber vessels and compliance mismatch between prosthetic and native vessel, respectively [1].

Download Full-text

Development of a Media Equivalent as a Foundation for a Biomimicking Vascular Prosthetic

10.1115/imece1999-0370 ◽

1999 ◽

Author(s):

Kristin J. Pawlowski ◽

Gary L. Bowlin

Keyword(s):

Blood Flow ◽

Large Diameter ◽

Small Diameter ◽

Thrombotic Occlusion ◽

Expanded Polytetrafluoroethylene ◽

Blood Flow Velocities ◽

Vascular Replacement ◽

Compliance Mismatch ◽

Flow Velocities

Abstract Development of an ideal vascular replacement has been addressed with increasing urgency in recent years. To date, appropriate replacements for only large diameter bypass have been realized, employing the use of Dacron and expanded polytetrafluoroethylene. A solution for small diameter vessel bypass, however, has not yet been found. This is due mainly to acute thrombotic occlusion and chronic anastomotic hyperplasia that is introduced into these grafts due to the low blood flow velocities experienced by smaller caliber vessels and compliance mismatch between prosthetic and native vessel, respectively [1].

Download Full-text