Angiogenesis and Full-Thickness Wound Healing Efficiency of a Copper-Doped Borate Bioactive Glass/Poly(lactic-co-glycolic acid) Dressing Loaded with Vitamin E in Vivo and in Vitro

2018 ◽  
Vol 10 (27) ◽  
pp. 22939-22950 ◽  
Author(s):  
Haoran Hu ◽  
Yue Tang ◽  
Libin Pang ◽  
Cunlong Lin ◽  
Wenhai Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Vitamin E ◽  
Bioactive Glass ◽  
Glycolic Acid ◽  
Full Thickness ◽  
Healing Efficiency ◽  
Borate Bioactive Glass ◽  
Full Thickness Wound

Development of a novel keratin dressing which accelerates full-thickness skin wound healing in diabetic mice: In vitro and in vivo studies

2018 ◽  
Vol 33 (4) ◽  
pp. 527-540 ◽  
Author(s):  
Marek Konop ◽  
Joanna Czuwara ◽  
Ewa Kłodzińska ◽  
Anna K Laskowska ◽  
Urszula Zielenkiewicz ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Skin Wound ◽  
In Vivo Studies ◽  
Histopathological Analysis ◽  
Full Thickness ◽  
Impaired Wound Healing

Impaired wound healing is a major medical problem in diabetes. The objective of this study was to determine the possible application of an insoluble fraction of fur-derived keratin biomaterial as a wound dressing in a full thickness surgical skin wound model in mice ( n = 20) with iatrogenically induced diabetes. The obtained keratin dressing was examined in vitro and in vivo. In vitro study showed the keratin dressing is tissue biocompatible and non-toxic for murine fibroblasts. Antimicrobial examination revealed the keratin dressing inhibited the growth of S. aureus and E. coli. In vivo studies showed the obtained dressing significantly ( p < 0.05) accelerated healing during the first week after surgery compared to control wounds. Keratin dressings were incorporated naturally into granulation and regenerating tissue without any visible signs of inflammatory response, which was confirmed by clinical and histopathological analysis. It is one of the first studies to show application of insoluble keratin proteins and its properties as a wound dressing. The obtained keratin dressing accelerated wound healing in mice with iatrogenically induced diabetes. Therefore, it can be considered as a safe and efficient wound dressing. Although future studies are needed to explain the molecular mechanism behind fur-derived keratin effect during the multilayer wound healing process, our findings may open the way for a new class of insoluble fur keratin dressings in chronic difficult to heal wounds treatment.

In Vivo and in Vitro Evaluation of Chitosan Modified Bioactive Glass Paste for Wound Healing

2022 ◽  
Author(s):  
shuai wu ◽  
Xiaoyang Cheng ◽  
Xiaomu Xu ◽  
Jiacheng Wu ◽  
Zhenzhao Guo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bioactive Glass ◽  
In Vitro Evaluation ◽  
Glass Paste

In this thesis, chitosan (CS) improving the properties of bioactive glass (BG) paste for wound healing was studied. Based on the evaluation in vitro, the addition of CS neutralizes the...

Promotion of Full-Thickness Wound Healing Using Epigallocatechin-3-O-Gallate/Poly (Lactic-Co-Glycolic Acid) Membrane as Temporary Wound Dressing

2013 ◽  
Vol 38 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Hye-Lee Kim ◽  
Jeong-Hyun Lee ◽  
Byeong Ju Kwon ◽  
Mi Hee Lee ◽  
Dong-Wook Han ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Glycolic Acid ◽  
Full Thickness ◽  
Full Thickness Wound
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