Synergistic Effect of Metal–Organic Framework/Gallic Acid in Enhanced Laser Desorption/Ionization Mass Spectrometry

2019 ◽  
Vol 11 (41) ◽  
pp. 38255-38264 ◽  
Author(s):  
Jie Wu ◽  
Dan Ouyang ◽  
Yanting He ◽  
Hang Su ◽  
Baichuan Yang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Synergistic Effect ◽  
Gallic Acid ◽  
Metal Organic Framework ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Metal Organic

Metal–organic frameworks: new matrices for surface-assisted laser desorption–ionization mass spectrometry

2013 ◽  
Vol 49 (43) ◽  
pp. 4929 ◽  
Author(s):  
Yung-Han Shih ◽  
Ching-Hsuan Chien ◽  
Brenda Singco ◽  
Chang-Lin Hsu ◽  
Chia-Her Lin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Metal Organic Frameworks ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization ◽  
Metal Organic

Synergistic Effect of Graphene Oxide/MWCNT Films in Laser Desorption/Ionization Mass Spectrometry of Small Molecules and Tissue Imaging

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 4550-4561 ◽  
Author(s):  
Young-Kwan Kim ◽  
Hee-Kyung Na ◽  
Sul-Jin Kwack ◽  
Soo-Ryoon Ryoo ◽  
Youngmi Lee ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Graphene Oxide ◽  
Synergistic Effect ◽  
Small Molecules ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Tissue Imaging ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Desorption Ionization

scholarly journals Diagnosis of Agglomeration and Crystallinity of Active Pharmaceutical Ingredients in Over the Counter Headache Medication by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 610
Author(s):  
Mariann Inga Van Meter ◽  
Salah M. Khan ◽  
Brynne V. Taulbee-Cotton ◽  
Nathan H. Dimmitt ◽  
Nathan D. Hubbard ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Active Pharmaceutical Ingredients ◽  
Laser Desorption Ionization ◽  
Over The Counter ◽  
Pharmaceutical Ingredients ◽  
Desorption Ionization

Agglomeration of active pharmaceutical ingredients (API) in tablets can lead to decreased bioavailability in some enabling formulations. In a previous study, we determined that crystalline APIs can be detected as agglomeration in tablets formulated with amorphous acetaminophen tablets. Multiple method advancements are presented to better resolve agglomeration caused by crystallinity in standard tablets. In this study, we also evaluate three “budget” over-the-counter headache medications (subsequently labeled as brands A, B, and C) for agglomeration of the three APIs in the formulation: Acetaminophen, aspirin, and caffeine. Electrospray laser desorption ionization mass spectrometry imaging (ELDI-MSI) was used to diagnose agglomeration in the tablets by creating molecular images and observing the spatial distributions of the APIs. Brand A had virtually no agglomeration or clustering of the active ingredients. Brand B had extensive clustering of aspirin and caffeine, but acetaminophen was observed in near equal abundance across the tablet. Brand C also had extensive clustering of aspirin and caffeine, and minor clustering of acetaminophen. These results show that agglomeration with active ingredients in over-the-counter tablets can be simultaneously detected using ELDI-MS imaging.

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