Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation

2019 ◽  
Vol 11 (39) ◽  
pp. 35566-35576 ◽  
Author(s):  
Ling-xiao Zhang ◽  
Xia-mei Sun ◽  
Zhi Ping Xu ◽  
Rui-tian Liu
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Invasive Breast Cancer ◽  
Primary Invasive Breast Cancer

Efficacy in Treating Lung Metastasis of Invasive Breast Cancer with Functional Vincristine Plus Dasatinib Liposomes

Pharmacology ◽  
2017 ◽  
Vol 101 (1-2) ◽  
pp. 43-53 ◽  
Author(s):  
Fan Zeng ◽  
Rui-Jun Ju ◽  
Lei Liu ◽  
Hong-Jun Xie ◽  
Li-Min Mu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Nude Mice ◽  
Invasive Breast Cancer ◽  
Metastatic Breast ◽  
Current Treatment ◽  
Migration And Invasion ◽  
Induce Cell Cycle Arrest ◽  
M Phase

Background: The metastasis of breast cancer is the leading cause of death, while lung metastasis is a major clinical phenomenon in patients with invasive breast cancer. The current treatment option comprising surgery, radiation, and standard chemotherapy cannot achieve a satisfactory effect on the treatment of lung metastasis of breast cancer. In this study, we report the potential of preventing lung metastasis of invasive breast cancer using the newly developed functional vincristine plus dasatinib liposomes. Methods: The investigations were performed on invasive breast cancer MDA-MB-231 cells in vitro and in lung metastatic model of invasive breast cancer MDA-MB-231 cells in nude mice. Results: The functional drug liposomes were able to induce cell cycle arrest at G2/M phase, induce apoptosis, inhibit adhesion, migration, and invasion of breast cancer cells in vitro, and prevent lung metastasis of breast cancer in nude mice. Conclusion: These findings indicate a potential clinical use of functional vincristine plus dasatinib liposomes for treating metastatic breast cancer.

scholarly journals LEA.135 expression: An independent and favorable prognostic biomarker for patients with primary invasive breast cancer

2000 ◽  
Vol 89 (3) ◽  
pp. 224-229 ◽  
Author(s):  
Dongxin Liu ◽  
Wesley Y. Naritoku ◽  
Denice Tsao-Wei ◽  
Susan Groshen ◽  
Munro A. Neville ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Prognostic Biomarker ◽  
Primary Invasive Breast Cancer
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