Cβ-Selective Aldol Addition of d-Threonine Aldolase by Spatial Constraint of Aldehyde Binding

ACS Catalysis ◽  
2021 ◽  
pp. 6892-6899
Author(s):  
Sung-Hyun Park ◽  
Hogyun Seo ◽  
Jihye Seok ◽  
Haseong Kim ◽  
Kil Koang Kwon ◽  
...  
Keyword(s):  
Spatial Constraint ◽  
Threonine Aldolase ◽  
Aldol Addition

Asymmetric Aldol Addition by Oligopeptide Immobilized on Magnetic Particles through an Ionic Liquids Spacer

2008 ◽  
Vol 47 (23) ◽  
pp. 9628-9635 ◽  
Author(s):  
Yangyang Jiang ◽  
Chen Guo ◽  
Hansong Xia ◽  
Iram Mahmood ◽  
Huizhou Liu
Keyword(s):  
Ionic Liquids ◽  
Magnetic Particles ◽  
Asymmetric Aldol ◽  
Aldol Addition

scholarly journals Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 211-226 ◽  
Author(s):  
Perla Ramesh ◽  
Devatha Suman ◽  
Koti Reddy
Keyword(s):  
Asymmetric Reduction ◽  
Asymmetric Hydrogenation ◽  
Asymmetric Aldol ◽  
Asymmetric Michael Addition ◽  
Chemical Resolution ◽  
Enzymatic Desymmetrization ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Synthetic Approaches ◽  
Catalytic Asymmetric Hydrogenation

Baclofen is an antispastic drug used as a muscle relaxant in the treatment of the paroxysmal pain of trigeminal neuralgia, spasticity of the spinal cord and cerebral origin. Baclofen resides biological activity exclusively in its (R)-(–)-enantiomer. In this review, various asymmetric synthetic strategies for (R)-(–)-baclofen are described.1 Introduction2 Resolution Synthetic Approaches2.1 Chemical Resolution2.2 Biocatalytic Resolution3 Asymmetric Desymmetrization3.1 Catalytic Enantioselective Desymmetrization3.2 Enzymatic Desymmetrization4 Chiral Auxiliary Induced Asymmetric Synthesis4.1 Asymmetric Michael Addition4.2 Asymmetric Aldol Addition4.3 Asymmetric Nucleophilic Substitution5 Asymmetric Reduction5.1 Catalytic Asymmetric Hydrogenation5.2 Bioreduction6 Catalytic Asymmetric Conjugate Addition7 Conclusion

scholarly journals l -Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase

2001 ◽  
Vol 268 (24) ◽  
pp. 6508-6525 ◽  
Author(s):  
Roberto Contestabile ◽  
Alessandro Paiardini ◽  
Stefano Pascarella ◽  
Martino L. di Salvo ◽  
Simona D'Aguanno ◽  
...  
Keyword(s):  
Serine Hydroxymethyltransferase ◽  
Alanine Racemase ◽  
Threonine Aldolase

The aldol addition reaction between γ-oxygenated carboxylic esters derived from 2,6-dimethylphenol and piperonal

1994 ◽  
Vol 35 (9) ◽  
pp. 1325-1328 ◽  
Author(s):  
Paulo R.R. Costa ◽  
Maria F.G. Fernandes ◽  
Sergio Pinheiro
Keyword(s):  
Addition Reaction ◽  
Aldol Addition ◽  
Carboxylic Esters

Efficient preparation of 3-substituted-furan-2(5H)-ones and their direct vinylogous aldol addition

Tetrahedron ◽  
2001 ◽  
Vol 57 (20) ◽  
pp. 4429-4436 ◽  
Author(s):  
Marco Bella ◽  
Giovanni Piancatelli ◽  
Antonella Squarcia
Keyword(s):  
Aldol Addition

Control of Six Contiguous Stereocenters in an Asymmetric Organocatalytic One-Pot Michael/Michael/Aldol Addition Sequence

2012 ◽  
Vol 354 (8) ◽  
pp. 1481-1488 ◽  
Author(s):  
Dieter Enders ◽  
Gregor Urbanietz ◽  
Elisa Cassens-Sasse ◽  
Sebastian Keeß ◽  
Gerhard Raabe
Keyword(s):  
One Pot ◽  
Aldol Addition

ChemInform Abstract: L-Threonine Aldolase in Organic Synthesis: Preparation of Novel β- Hydroxy-α-amino Acids.

ChemInform ◽  
2010 ◽  
Vol 26 (46) ◽  
pp. no-no
Author(s):  
V. P. VASSILEV ◽  
T. UCHIYAMA ◽  
T. KAJIMOTO ◽  
C.-H. WONG
Keyword(s):  
Amino Acids ◽  
Organic Synthesis ◽  
Threonine Aldolase

Expanding the scope of the asymmetric anti-aldol addition of chiral N-amino cyclic carbamate hydrazones

2013 ◽  
Vol 54 (40) ◽  
pp. 5470-5472 ◽  
Author(s):  
John D. Knight ◽  
Don M. Coltart
Keyword(s):  
Aldol Addition
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