Self-Assembled Thermoresponsive Molecular Brushes as Nanoreactors for Asymmetric Aldol Addition in Water

2021 ◽  
Author(s):  
Michael Kuepfert ◽  
Eman Ahmed ◽  
Marcus Weck
Keyword(s):  
Asymmetric Aldol ◽  
Molecular Brushes ◽  
Self Assembled ◽  
Aldol Addition

Asymmetric Aldol Addition by Oligopeptide Immobilized on Magnetic Particles through an Ionic Liquids Spacer

2008 ◽  
Vol 47 (23) ◽  
pp. 9628-9635 ◽  
Author(s):  
Yangyang Jiang ◽  
Chen Guo ◽  
Hansong Xia ◽  
Iram Mahmood ◽  
Huizhou Liu
Keyword(s):  
Ionic Liquids ◽  
Magnetic Particles ◽  
Asymmetric Aldol ◽  
Aldol Addition

scholarly journals Asymmetric Synthetic Strategies of (R)-(–)-Baclofen: An Antispastic Drug

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 211-226 ◽  
Author(s):  
Perla Ramesh ◽  
Devatha Suman ◽  
Koti Reddy
Keyword(s):  
Asymmetric Reduction ◽  
Asymmetric Hydrogenation ◽  
Asymmetric Aldol ◽  
Asymmetric Michael Addition ◽  
Chemical Resolution ◽  
Enzymatic Desymmetrization ◽  
Catalytic Asymmetric ◽  
Aldol Addition ◽  
Synthetic Approaches ◽  
Catalytic Asymmetric Hydrogenation

Baclofen is an antispastic drug used as a muscle relaxant in the treatment of the paroxysmal pain of trigeminal neuralgia, spasticity of the spinal cord and cerebral origin. Baclofen resides biological activity exclusively in its (R)-(–)-enantiomer. In this review, various asymmetric synthetic strategies for (R)-(–)-baclofen are described.1 Introduction2 Resolution Synthetic Approaches2.1 Chemical Resolution2.2 Biocatalytic Resolution3 Asymmetric Desymmetrization3.1 Catalytic Enantioselective Desymmetrization3.2 Enzymatic Desymmetrization4 Chiral Auxiliary Induced Asymmetric Synthesis4.1 Asymmetric Michael Addition4.2 Asymmetric Aldol Addition4.3 Asymmetric Nucleophilic Substitution5 Asymmetric Reduction5.1 Catalytic Asymmetric Hydrogenation5.2 Bioreduction6 Catalytic Asymmetric Conjugate Addition7 Conclusion

Influence of a remote sulfinyl group on l -proline-catalyzed direct asymmetric aldol addition of acetone

Tetrahedron ◽  
2016 ◽  
Vol 72 (35) ◽  
pp. 5414-5419 ◽  
Author(s):  
Rosaria Villano ◽  
Maria Rosaria Acocella ◽  
Arrigo Scettri
Keyword(s):  
Asymmetric Aldol ◽  
Aldol Addition ◽  
Sulfinyl Group

ChemInform Abstract: Asymmetric Aldol Addition of Aldehydes to a Difluoroketene Silyl Acetal Catalyzed by Chiral Lewis Acids.

ChemInform ◽  
2010 ◽  
Vol 28 (51) ◽  
pp. no-no
Author(s):  
K. ISEKI ◽  
Y. KUROKI ◽  
D. ASADA ◽  
M. TAKAHASHI ◽  
S. KISHIMOTO ◽  
...  
Keyword(s):  
Lewis Acids ◽  
Asymmetric Aldol ◽  
Aldol Addition

Lewis Base Catalyzed Asymmetric Aldol Addition of Oxyketene Imines to Aldehydes

Synfacts ◽  
2011 ◽  
Vol 2011 (02) ◽  
pp. 0177-0177
Author(s):  
S. Denmark ◽  
T. Wilson
Keyword(s):  
Lewis Base ◽  
Asymmetric Aldol ◽  
Aldol Addition

scholarly journals Organocatalytic Asymmetric Aldol Reaction of Arylglyoxals and Hydroxyacetone: Enantioselective Synthesis of 2,3-Dihydroxy-1,4-diones

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 648
Author(s):  
Yu-Hao Zhou ◽  
Yu-Zu Zhang ◽  
Zhu-Lian Wu ◽  
Tian Cai ◽  
Wei Wen ◽  
...  
Keyword(s):  
Primary Amine ◽  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Highly Efficient ◽  
Asymmetric Aldol Reaction ◽  
Aldol Addition ◽  
High Yields

A highly efficient quinine-derived primary-amine-catalyzed asymmetric aldol addition of hydroxyacetone to arylglyoxals is described. Structurally diverse anti-2,3-dihydroxy-1,4-diones were generated in high yields, with good diastereoselectivities and enantioselectivities.

ChemInform Abstract: Influence of a Remote Sulfinyl Group on L-Proline-Catalyzed Direct Asymmetric Aldol Addition of Acetone.

ChemInform ◽  
2016 ◽  
Vol 47 (50) ◽  
Author(s):  
Rosaria Villano ◽  
Maria Rosaria Acocella ◽  
Arrigo Scettri
Keyword(s):  
Asymmetric Aldol ◽  
Aldol Addition ◽  
Sulfinyl Group

Copolymer-supported heterogeneous organocatalyst for asymmetric aldol addition in aqueous medium

2012 ◽  
Vol 10 (21) ◽  
pp. 4179 ◽  
Author(s):  
Jinqing Zhou ◽  
Jinwei Wan ◽  
Xuebing Ma ◽  
Wei Wang
Keyword(s):  
Aqueous Medium ◽  
Asymmetric Aldol ◽  
Aldol Addition
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