scholarly journals Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry

ACS Nano ◽  
2016 ◽  
Vol 10 (1) ◽  
pp. 1417-1424 ◽  
Author(s):  
Shuang Hou ◽  
Jin-sil Choi ◽  
Mitch Andre Garcia ◽  
Yan Xing ◽  
Kuan-Ju Chen ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Bioorthogonal Chemistry ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Supramolecular Nanoparticles

scholarly journals Development of 2-Deoxy-2-[18F]fluororibose for Positron Emission Tomography Imaging Liver Function in Vivo

2015 ◽  
Vol 58 (14) ◽  
pp. 5538-5547 ◽  
Author(s):  
Nikolai M. Evdokimov ◽  
Peter M. Clark ◽  
Graciela Flores ◽  
Timothy Chai ◽  
Kym F. Faull ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Liver Function ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Positron Emission

scholarly journals In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia

2004 ◽  
Vol 101 (31) ◽  
pp. 11438-11443 ◽  
Author(s):  
C. K. Abbey ◽  
A. D. Borowsky ◽  
E. T. McGoldrick ◽  
J. P. Gregg ◽  
J. E. Maglione ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Mouse Model ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Mammary Neoplasia

scholarly journals In vivo targeting and positron emission tomography imaging of tumor vasculature with 66Ga-labeled nano-graphene

Biomaterials ◽  
2012 ◽  
Vol 33 (16) ◽  
pp. 4147-4156 ◽  
Author(s):  
Hao Hong ◽  
Yin Zhang ◽  
Jonathan W. Engle ◽  
Tapas R. Nayak ◽  
Charles P. Theuer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Positron Emission Tomography Imaging ◽  
Tumor Vasculature ◽  
Emission Tomography ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Nano Graphene

scholarly journals Diphenhydramine as a selective probe to study H+-antiporter function at the blood–brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging

2016 ◽  
Vol 37 (6) ◽  
pp. 2185-2195 ◽  
Author(s):  
Sylvain Auvity ◽  
Hélène Chapy ◽  
Sébastien Goutal ◽  
Fabien Caillé ◽  
Benoit Hosten ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Brain Barrier ◽  
Positron Emission Tomography Imaging ◽  
Emission Tomography ◽  
Brain Barrier ◽  
Tomography Imaging ◽  
Blood Brain ◽  
Positron Emission ◽  
The Brain

Diphenhydramine, a sedative histamine H1-receptor (H1R) antagonist, was evaluated as a probe to measure drug/H+-antiporter function at the blood–brain barrier. In situ brain perfusion experiments in mice and rats showed that diphenhydramine transport at the blood–brain barrier was saturable, following Michaelis–Menten kinetics with a Km = 2.99 mM and Vmax = 179.5 nmol s−1 g−1. In the pharmacological plasma concentration range the carrier-mediated component accounted for 77% of diphenhydramine influx while passive diffusion accounted for only 23%. [14C]Diphenhydramine blood–brain barrier transport was proton and clonidine sensitive but was influenced by neither tetraethylammonium, a MATE1 (SLC47A1), and OCT/OCTN (SLC22A1-5) modulator, nor P-gp/Bcrp (ABCB1a/1b/ABCG2) deficiency. Brain and plasma kinetics of [11C]diphenhydramine were measured by positron emission tomography imaging in rats. [11C]Diphenhydramine kinetics in different brain regions were not influenced by displacement with 1 mg kg−1 unlabeled diphenhydramine, indicating the specificity of the brain positron emission tomography signal for blood–brain barrier transport activity over binding to any central nervous system target in vivo. [11C]Diphenhydramine radiometabolites were not detected in the brain 15 min after injection, allowing for the reliable calculation of [11C]diphenhydramine brain uptake clearance (Clup = 0.99 ± 0.18 mL min−1 cm−3). Diphenhydramine is a selective and specific H+-antiporter substrate. [11C]Diphenhydramine positron emission tomography imaging offers a reliable and noninvasive method to evaluate H+-antiporter function at the blood–brain barrier.

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