scholarly journals Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano ◽  
2018 ◽  
Vol 12 (7) ◽  
pp. 6536-6544 ◽  
Author(s):  
Hongxia Liang ◽  
Ke Huang ◽  
Teng Su ◽  
Zhenhua Li ◽  
Shiqi Hu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Carbon Tetrachloride ◽  
Mesenchymal Stem Cell ◽  
Blood Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Red Blood Cell

Attenuation of Postoperative Acute Liver Failure by Mesenchymal Stem Cell Treatment Due to Metabolic Implications

2016 ◽  
Vol 263 (3) ◽  
pp. 546-556 ◽  
Author(s):  
Hans-Michael Tautenhahn ◽  
Sandra Brückner ◽  
Sven Baumann ◽  
Sandra Winkler ◽  
Wolfgang Otto ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Stem Cell Treatment ◽  
Mesenchymal Stem Cell Treatment

scholarly journals Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure

2020 ◽  
Vol 34 (2) ◽  
pp. 100-108
Author(s):  
Cheng-Maw Ho ◽  
Ya-Hui Chen ◽  
Chin-Sung Chien ◽  
Shu-Li Ho ◽  
Hui-Ling Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure

scholarly journals Application of mesenchymal stem cell exosomes and their drug‐loading systems in acute liver failure

2020 ◽  
Vol 24 (13) ◽  
pp. 7082-7093 ◽  
Author(s):  
Shuqin Zhang ◽  
Yu Hou ◽  
Jing Yang ◽  
Denghui Xie ◽  
Linrui Jiang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Drug Loading

Hepatocyte and Mesenchymal Stem Cell Co-Transplantation in Rats of Acute Liver Failure

2017 ◽  
Vol 15 (1) ◽  
pp. 151-152
Author(s):  
Cheng-Maw Ho ◽  
Ya-Hui Chen ◽  
Chin-Sung Chien ◽  
Shu-Li Ho ◽  
Daniel Tzu-bi Shih ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Liver Failure ◽  
Acute Liver Failure

scholarly journals Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jinglin Wang ◽  
Yang Liu ◽  
Haoran Ding ◽  
Xiaolei Shi ◽  
Haozhen Ren
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Inflammatory Response ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Prostaglandin E ◽  
Inflammasome Activation ◽  
M2 Macrophages ◽  
Promising Therapeutic Approach ◽  
Hepatocyte Death

Abstract Background Acute liver failure (ALF) is an acute inflammatory liver disease with high mortality. Previous preclinical and clinical trials have confirmed that mesenchymal stem cell (MSC) is a promising therapeutic approach; however, the effect is not satisfied as the underlying molecular mechanisms of MSC in treating ALF remain unclear. Methods MSC isolated from 4- to 6-week-old C57BL/6 mice were used to treat ALF. Histological and serological parameters were analyzed to evaluate the efficacy of MSC. We explored the molecular mechanism of MSC in the treatment of ALF by detecting liver inflammatory response and hepatocyte death. Results In this study, we found that the therapeutic potential of MSC on ALF is dependent on the secretion of prostaglandin E2 (PGE2), a bioactive lipid. MSC-derived PGE2 inhibited TGF-β-activated kinase 1 (TAK1) signaling and NLRP3 inflammasome activation in liver macrophages to decrease the production of inflammatory cytokines. Meanwhile, macrophages in the liver could be induced to anti-inflammatory (M2) macrophages by MSC-derived PGE2 via STAT6 and mechanistic target of rapamycin (mTOR) signaling, which then promote inflammatory resolution and limit liver injury. Finally, administrating EP4 antagonist significantly ameliorated the therapeutic ability of MSC, which promoted liver inflammation and decreased M2 macrophages. Conclusions Our results indicate that PGE2 might be a novel important mediator of MSC in treating ALF, which is through inhibiting the liver inflammatory response and hepatocyte death.

Sign in / Sign up

Export Citation Format

Share Document