scholarly journals Good Manufacturing Practice Strategy for Antibody–Drug Conjugate Synthesis Using Site-Specific Chemical Conjugation: First-Generation AJICAP

ACS Omega ◽  
2019 ◽  
Vol 4 (24) ◽  
pp. 20564-20570 ◽  
Author(s):  
Yutaka Matsuda ◽  
Colin Clancy ◽  
Zhala Tawfiq ◽  
Veronica Robles ◽  
Brian A. Mendelsohn
Keyword(s):  
First Generation ◽  
Good Manufacturing Practice ◽  
Antibody Drug Conjugate ◽  
Specific Chemical ◽  
Site Specific ◽  
Drug Conjugate ◽  
Chemical Conjugation ◽  
Antibody Drug

Gram-Scale Antibody–Drug Conjugate Synthesis by Site-Specific Chemical Conjugation: AJICAP First Generation

2019 ◽  
Vol 23 (12) ◽  
pp. 2647-2654 ◽  
Author(s):  
Yutaka Matsuda ◽  
Kei Yamada ◽  
Tatsuya Okuzumi ◽  
Brian A. Mendelsohn
Keyword(s):  
First Generation ◽  
Antibody Drug Conjugate ◽  
Specific Chemical ◽  
Site Specific ◽  
Drug Conjugate ◽  
Chemical Conjugation ◽  
Antibody Drug

A CXCR4-Targeted Site-Specific Antibody-Drug Conjugate

2014 ◽  
Vol 126 (44) ◽  
pp. 12057-12061 ◽  
Author(s):  
Sumith A. Kularatne ◽  
Vishal Deshmukh ◽  
Jennifer Ma ◽  
Virginie Tardif ◽  
Reyna K. V. Lim ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody–drug Conjugate (ARX788) for Breast Cancer Treatment

2020 ◽  
Vol 19 (9) ◽  
pp. 1822-1832
Author(s):  
Prathap Nagaraja Shastri ◽  
Jingjing Zhu ◽  
Lillian Skidmore ◽  
Xuejun Liang ◽  
Yanping Ji ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Breast Cancer Treatment ◽  
Next Generation ◽  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
Antibody Drug

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

2013 ◽  
Vol 24 (7) ◽  
pp. 1256-1263 ◽  
Author(s):  
Scott C. Jeffrey ◽  
Patrick J. Burke ◽  
Robert P. Lyon ◽  
David W. Meyer ◽  
Django Sussman ◽  
...  
Keyword(s):  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers

2020 ◽  
Vol 19 (9) ◽  
pp. 1833-1843 ◽  
Author(s):  
Lillian Skidmore ◽  
Sukumar Sakamuri ◽  
Nick A. Knudsen ◽  
Amha Gebre Hewet ◽  
Snezana Milutinovic ◽  
...  
Keyword(s):  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Gastric Cancers ◽  
Drug Conjugate ◽  
A Site ◽  
Antibody Drug ◽  
Selective Activity

scholarly journals A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry

2019 ◽  
Vol 30 (11) ◽  
pp. 2419-2429 ◽  
Author(s):  
Oscar Hernandez-Alba ◽  
Stéphane Houel ◽  
Steve Hessmann ◽  
Stéphane Erb ◽  
David Rabuka ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Specific Antibody ◽  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
Drug Conjugation ◽  
A Site ◽  
Antibody Drug

scholarly journals Targeted Delivery of LXR Agonist Using a Site-Specific Antibody–Drug Conjugate

2015 ◽  
Vol 26 (11) ◽  
pp. 2216-2222 ◽  
Author(s):  
Reyna K. V. Lim ◽  
Shan Yu ◽  
Bo Cheng ◽  
Sijia Li ◽  
Nam-Jung Kim ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Targeted Delivery ◽  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
A Site ◽  
Antibody Drug

Abstract 639: Site specific conjugation of ARX-788, an antibody drug conjugate (ADC) targeting HER2, generates a potent and stable targeted therapeutic for multiple cancers

2015 ◽  
Author(s):  
Robin C. Humphreys ◽  
Jessica Kirtely ◽  
Amha Hewit ◽  
Sandra Biroc ◽  
Nick Knudsen ◽  
...  
Keyword(s):  
Antibody Drug Conjugate ◽  
Site Specific ◽  
Drug Conjugate ◽  
Multiple Cancers ◽  
Antibody Drug ◽  
Targeted Therapeutic
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