scholarly journals Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates

2014 ◽  
Vol 25 (11) ◽  
pp. 2081-2085 ◽  
Author(s):  
Randy J. Giedt ◽  
Melissa M. Sprachman ◽  
Katherine S. Yang ◽  
Ralph Weissleder
Keyword(s):  
Small Molecule ◽  
Cellular Distribution ◽  
Small Molecule Drug ◽  
Drug Conjugates

scholarly journals Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

2018 ◽  
Vol 24 (15) ◽  
pp. 3656-3667 ◽  
Author(s):  
Samuele Cazzamalli ◽  
Barbara Ziffels ◽  
Fontaine Widmayer ◽  
Patrizia Murer ◽  
Giovanni Pellegrini ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Small Molecule ◽  
Interleukin 2 ◽  
Carbonic Anhydrase Ix ◽  
Therapeutic Activity ◽  
Small Molecule Drug ◽  
Drug Conjugates

Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment

2019 ◽  
Vol 163 ◽  
pp. 883-895 ◽  
Author(s):  
Chunlin Zhuang ◽  
Xianghong Guan ◽  
Hao Ma ◽  
Hui Cong ◽  
Wannian Zhang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Targeted Treatment ◽  
Small Molecule Drug ◽  
Drug Conjugates ◽  
Novel Strategy

Small molecule drug conjugates (SMDCs): an emerging strategy for anticancer drug design and discovery

2021 ◽  
Vol 45 (12) ◽  
pp. 5291-5321
Author(s):  
Tarun Kumar Patel ◽  
Nilanjan Adhikari ◽  
Sk. Abdul Amin ◽  
Swati Biswas ◽  
Tarun Jha ◽  
...  
Keyword(s):  
Drug Design ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Chemotherapeutic Agents ◽  
Drug Molecule ◽  
Lysosomal Ph ◽  
Small Molecule Drug ◽  
Drug Conjugates ◽  
Small Molecule Drugs ◽  
Tumor Environment

Mechanisms of how SMDCs work. Small molecule drugs are conjugated with the targeted ligand using pH sensitive linkers which allow the drug molecule to get released at lower lysosomal pH. It helps to accumulate the chemotherapeutic agents to be localized in the tumor environment upon cleaving of the pH-labile bonds.

Abstract B066: Development of paired small-molecule drug conjugates for prostate cancer precision theranostics

2018 ◽  
Author(s):  
Bing Guan ◽  
Yunkou Wu ◽  
Jingyue Yang ◽  
Yahong Xiong ◽  
Jer-Tsong Hsieh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Molecule ◽  
Small Molecule Drug ◽  
Drug Conjugates
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