Sequential resonance assignments in proton NMR spectra of oligonucleotides by two-dimensional NMR spectroscopy

Biochemistry ◽  
1984 ◽  
Vol 23 (7) ◽  
pp. 1371-1376 ◽  
Author(s):  
R. M. Scheek ◽  
R. Boelens ◽  
N. Russo ◽  
J. H. Van Boom ◽  
R. Kaptein
Keyword(s):  
Nmr Spectroscopy ◽  
Nmr Spectra ◽  
Proton Nmr ◽  
Resonance Assignments ◽  
Two Dimensional

Chemical shift correlated two-dimensional nmr spectroscopy and its application to solving the proton nmr spectra of oligoribonucleotides

1980 ◽  
Vol 58 (18) ◽  
pp. 1947-1956 ◽  
Author(s):  
Alex D. Bain ◽  
Russell A. Bell ◽  
Jeremy R. Everett ◽  
Donald W. Hughes
Keyword(s):  
Nmr Spectroscopy ◽  
Chemical Shift ◽  
Nmr Spectra ◽  
Pulse Sequence ◽  
Chemical Shifts ◽  
Proton Nmr ◽  
Two Dimensional

An alternative two-dimensional nmr pulse sequence, (90°–t1/2–90°–t1/2–FID),correlates the chemical shifts of coupled nuclei. The application of this technique to the solution of the complicated proton nmr spectra of oligoribonucleotides is discussed.

Sequential resonance assignments in DNA proton NMR spectra by two-dimensional NOE spectroscopy

1983 ◽  
Vol 105 (9) ◽  
pp. 2914-2916 ◽  
Author(s):  
R. M. Scheek ◽  
N. Russo ◽  
R. Boelens ◽  
R. Kaptein ◽  
J. H. Van Boom
Keyword(s):  
Nmr Spectra ◽  
Proton Nmr ◽  
Resonance Assignments ◽  
Two Dimensional

ChemInform Abstract: SEQUENTIAL RESONANCE ASSIGNMENTS IN DNA PROTON NMR SPECTRA BY TWO-DIMENSIONAL NOE SPECTROSCOPY

1983 ◽  
Vol 14 (32) ◽  
Author(s):  
R. M. SCHEEK ◽  
N. RUSSO ◽  
R. BOELENS ◽  
R. KAPTEIN ◽  
J. H. VAN BOOM
Keyword(s):  
Nmr Spectra ◽  
Proton Nmr ◽  
Resonance Assignments ◽  
Two Dimensional

Structural studies of digitoxin and related cardenolides by two-dimensional NMR

1990 ◽  
Vol 68 (2) ◽  
pp. 272-277 ◽  
Author(s):  
Torbjörn Drakenberg ◽  
Peter Brodelius ◽  
Deane D. McIntyre ◽  
Hans J Vogel
Keyword(s):  
Nmr Spectroscopy ◽  
Nmr Spectra ◽  
Chair Conformation ◽  
Coupling Constants ◽  
Two Dimensional ◽  
Structural Studies ◽  
Solution Conformation ◽  
Phase Sensitive ◽  
Multiple Relay ◽  
C Nmr

The 1H and 13C NMR spectra of the cardenolides digitoxigenin, digoxigenin, digitoxin, and mono- and bis-digitoxigenin digitoxosides have been completely assigned by two-dimensional NMR spectroscopy. The techniques used include phase-sensitive COSY, multiple relay COSY, and carbon–proton correlation (HETCOR and HMQC) spectra. Various aspects of the solution conformation of the steroid moiety of digitoxin and digoxigenin could be determined from coupling constants and NOE difference experiments and they are indicative of an all-chair conformation. The carbohydrate rings in digitoxin and the mono- and bis-digitoxigenin digitoxosides are also in the chair conformation. Keywords: cardenolides, digitoxigenin, digitoxin, 2-dimensional NMR, conformational analysis.

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