Uncoupling of ATP binding to sodium-potassium ATPase from its stimulation of ouabain binding: studies of the inhibition of sodium-potassium ATPase by a monoclonal antibody

Biochemistry ◽  
1986 ◽  
Vol 25 (22) ◽  
pp. 7155-7162 ◽  
Author(s):  
William J. Ball
Keyword(s):  
Monoclonal Antibody ◽  
Atp Binding ◽  
Binding Studies ◽  
Ouabain Binding ◽  
Sodium Potassium ◽  
Potassium Atpase ◽  
Stimulation Of

Endothelin-1 stimulation of aldosterone and zona glomerulosa ouabain-sensitive sodium/potassium-ATPase

1994 ◽  
Vol 50 (1-2) ◽  
pp. 49-53 ◽  
Author(s):  
Adali Pecci ◽  
Eduardo N. Cozza ◽  
Maura Devlin ◽  
Celso E. Gomez-Sanchez ◽  
Elise P. Gomez-Sanchez
Keyword(s):  
Zona Glomerulosa ◽  
Sodium Potassium ◽  
Endothelin 1 ◽  
Potassium Atpase ◽  
Stimulation Of

N-Acetylimidazole inactivates renal sodium-potassium ATPase by disrupting ATP binding to the catalytic site

Biochemistry ◽  
1990 ◽  
Vol 29 (24) ◽  
pp. 5775-5782 ◽  
Author(s):  
Jose M. Arguello ◽  
Jack H. Kaplan
Keyword(s):  
Catalytic Site ◽  
Atp Binding ◽  
Sodium Potassium ◽  
Potassium Atpase

Adenosine Receptor Modulation of Hypoxic-ischemic Injury in Striatum of Newborn Piglets

2020 ◽  
Vol 17 (4) ◽  
pp. 510-517
Author(s):  
Santiago Ortega-Gutierrez ◽  
Brandy Jones ◽  
Alan Mendez-Ruiz ◽  
Pankhil Shah ◽  
Michel T. Torbey
Keyword(s):  
Oxidative Stress ◽  
Atpase Activity ◽  
Neuronal Injury ◽  
Receptor Activation ◽  
Adult Mortality ◽  
Vehicle Group ◽  
Sodium Potassium ◽  
Receptor Modulation ◽  
A2a Receptor ◽  
Potassium Atpase

Background: Hypoxic-ischemic encephalopathy (HIE) is a major cause of pediatric and adult mortality and morbidity. Unfortunately, to date, no effective treatment has been identified. In the striatum, neuronal injury is analogous to the cellular mechanism of necrosis observed during NMethyl- D-Aspartate (NMDA) excitotoxicity. Adenosine acts as a neuromodulator in the central nervous system, the role of which relies mostly on controlling excitatory glutamatergic synapses. Objective: To examine the effect of pretreatment of SCH58261, an adenosine 2A (A2A) receptor antagonist and modulator of NMDA receptor function, following hypoxic-ischemia (HI) on sodium- potassium ATPase (Na+, K+-ATPase) activity and oxidative stress. Methods: Piglets (4-7 days old) were subjected to 30 min hypoxia and 7 min of airway occlusion producing asphyxic cardiac arrest. Groups were divided into four categories: HI samples were divided into HI-vehicle group (n = 5) and HI-A2A group (n = 5). Sham controls were divided into Sham vehicle (n = 5) and Sham A2A (n = 5) groups. Vehicle groups were pretreated with 0.9% saline, whereas A2A animals were pretreated with SCH58261 10 min prior to intervention. Striatum samples were collected 3 h post-arrest. Sodium-potassium ATPase (Na+, K+-ATPase) activity, malondialdehyde (MDA) + 4-hydroxyalkenals (4-HDA) and glutathione (GSH) levels were compared. Results: Pretreatment with SCH58261 significantly attenuated the decrease in Na+, K+-ATPase, decreased MDA+4-HDA levels and increased GSH in the HI-A2A group when compared to HIvehicle. Conclusion: A2A receptor activation may contribute to neuronal injury in newborn striatum after HI in association with decreased Na+, K+-ATPase activity and increased oxidative stress.

scholarly journals Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8

2003 ◽  
Vol 278 (18) ◽  
pp. 15565-15570 ◽  
Author(s):  
Liqing Yu ◽  
Jennifer York ◽  
Klaus von Bergmann ◽  
Dieter Lutjohann ◽  
Jonathan C. Cohen ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Liver X Receptor ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Cholesterol Excretion ◽  
Liver X Receptor Agonist ◽  
Stimulation Of ◽  
Atp Binding Cassette

scholarly journals Characterization and partial purification of the sodium-potassium-ATPase inhibitor released from cultured rat hypothalamic cells.

1985 ◽  
Vol 260 (25) ◽  
pp. 13595-13600 ◽  
Author(s):  
K Morgan ◽  
M D Lewis ◽  
G Spurlock ◽  
P A Collins ◽  
S M Foord ◽  
...  
Keyword(s):  
Partial Purification ◽  
Atpase Inhibitor ◽  
Sodium Potassium ◽  
Hypothalamic Cells ◽  
Potassium Atpase

scholarly journals Na,K-ATPase extracellular surface probed with a monoclonal antibody that enhances ouabain binding.

1992 ◽  
Vol 267 (19) ◽  
pp. 13694-13701 ◽  
Author(s):  
E Arystarkhova ◽  
M Gasparian ◽  
N.N. Modyanov ◽  
K.J. Sweadner
Keyword(s):  
Monoclonal Antibody ◽  
Ouabain Binding
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