Quantitative determination of the number of secondary and tertiary structure base pairs in transfer RNA in solution

Biochemistry ◽  
1976 ◽  
Vol 15 (20) ◽  
pp. 4370-4377 ◽  
Author(s):  
P. H. Bolton ◽  
C. R. Jones ◽  
D. Bastedo-Lerner ◽  
K. L. Wong ◽  
D. R. Kearns
2002 ◽  
Vol 30 (6) ◽  
pp. 1162-1166 ◽  
Author(s):  
T. R. Cech

In 1982 we reported the first catalytic RNA or ribozyme: the self-splicing intron of the Tetrahymena pre-rRNA. Additional examples of natural ribozymes were soon found, and research in the field focused on their enzymic mechanism and secondary and tertiary structure. Ribozymes identified through in vitro selection extended the repertoire of RNA catalysis. Two directions of current and future interest are the determination of atomic-resolution structures of large ribozymes by X-ray crystallography and the structural and mechanistic analysis of complexes of ribozymes with protein facilitators of their activity.


Nature ◽  
1976 ◽  
Vol 262 (5567) ◽  
pp. 423-424 ◽  
Author(s):  
PHILIP H. BOLTON ◽  
DAVID R. KEARNS

Biochemistry ◽  
1977 ◽  
Vol 16 (10) ◽  
pp. 2086-2094 ◽  
Author(s):  
Brian R. Reid ◽  
N. Susan Ribeiro ◽  
Lillian McCollum ◽  
Joseph Abbate ◽  
Ralph E. Hurd

1999 ◽  
Vol 96 (9/10) ◽  
pp. 1608-1615
Author(s):  
T. E. Malliavin ◽  
H. Desvaux ◽  
M. A. Delsuc

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