Participation of Critical Residues from the Extreme C-Terminal End of the Human Androgen Receptor in the Ligand Binding Function†

Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity

Protein Science ◽

10.1110/ps.051905906 ◽

2006 ◽

Vol 15 (5) ◽

pp. 987-999 ◽

Cited By ~ 149

Author(s):

Karine Pereira de Jésus-Tran ◽

Pierre-Luc Côté ◽

Line Cantin ◽

Jonathan Blanchet ◽

Fernand Labrie ◽

...

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Crystal Structures ◽

Binding Affinity ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Molecular Determinants ◽

Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain

Journal of Biological Chemistry ◽

10.1074/jbc.274.52.37219 ◽

1999 ◽

Vol 274 (52) ◽

pp. 37219-37225 ◽

Cited By ~ 246

Author(s):

Bin He ◽

Jon A. Kemppainen ◽

Johannes J. Voegel ◽

Hinrich Gronemeyer ◽

Elizabeth M. Wilson

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Activation Function ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Terminal Domain ◽

Human Androgen Receptor ◽

Interdomain Communication

Acta Crystallographica Section F Structural Biology and Crystallization Communications ◽

Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226

10.1107/s1744309106039340 ◽

2006 ◽

Vol 62 (11) ◽

pp. 1067-1071 ◽

Cited By ~ 26

Author(s):

Feng Wang ◽

Xiao-qin Liu ◽

He Li ◽

Kai-ni Liang ◽

Jeffrey N. Miner ◽

...

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Homology Modeling Using Multiple Molecular Dynamics Simulations and Docking Studies of the Human Androgen Receptor Ligand Binding Domain Bound to Testosterone and Nonsteroidal Ligands†

10.1021/jm0005353 ◽

2001 ◽

Vol 44 (11) ◽

pp. 1729-1740 ◽

Cited By ~ 59

Author(s):

Craig A. Marhefka ◽

Bob M. Moore ◽

Thomas C. Bishop ◽

Leonid Kirkovsky ◽

Arnab Mukherjee ◽

...

Keyword(s):

Molecular Dynamics ◽

Androgen Receptor ◽

Ligand Binding ◽

Homology Modeling ◽

Molecular Dynamics Simulations ◽

Docking Studies ◽

Binding Domain ◽

Receptor Ligand ◽

Dynamics Simulations ◽

Correction to Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening

10.1021/jm201689y ◽

2011 ◽

Vol 55 (1) ◽

pp. 565-565 ◽

Cited By ~ 2

Author(s):

Nathan A. Lack ◽

Peter Axerio-Cilies ◽

Peyman Tavassoli ◽

Frank Q. Han ◽

Ka Hong Chan ◽

...

Keyword(s):

Androgen Receptor ◽

Virtual Screening ◽

Binding Function ◽

Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer

10.1021/acs.jmedchem.1c00681 ◽

2021 ◽

Author(s):

Eric Leblanc ◽

Fuqiang Ban ◽

Ayse Derya Cavga ◽

Sam Lawn ◽

Chia-Chi Flora Huang ◽

...

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Castration Resistant Prostate Cancer ◽

Receptor Targeting ◽

Castration Resistant ◽

Binding Function ◽

Evidence that lack of ligand-binding domain correlates with nuclear distribution of unliganded human androgen receptor and loss of transactivation activity

Gynecological Endocrinology ◽

10.3109/09513590.2011.569599 ◽

2011 ◽

Vol 27 (11) ◽

pp. 940-943

Author(s):

Noriko Suzuki ◽

Atsushi Imai

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Transactivation Activity ◽

Nuclear Distribution ◽

Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.

10.1021/jm201098n ◽

2011 ◽

Vol 54 (24) ◽

pp. 8563-8573 ◽

Cited By ~ 91

Author(s):

Nathan A. Lack ◽

Peter Axerio-Cilies ◽

Peyman Tavassoli ◽

Frank Q. Han ◽

Ka Hong Chan ◽

...

Keyword(s):

Androgen Receptor ◽

Virtual Screening ◽

Binding Function ◽

Hormone-binding and solubility properties of fusion proteins containing the ligand-binding domain of the human androgen receptor

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/0960-0760(95)00273-1 ◽

1996 ◽

Vol 57 (3-4) ◽

pp. 251-257 ◽

Cited By ~ 3

Author(s):

B. Cooper ◽

J.A. Gruber ◽

M.J. McPhaul

Keyword(s):

Androgen Receptor ◽

Ligand Binding ◽

Fusion Proteins ◽

Binding Domain ◽

Ligand Binding Domain ◽

Hormone Binding ◽

Partial association of restriction polymorphism of the ligand binding domain of human androgen receptor in prostate cancer

Egyptian Journal of Medical Human Genetics ◽

10.1016/j.ejmhg.2015.09.004 ◽

2016 ◽

Vol 17 (2) ◽

pp. 223-228

Author(s):

Mohamed Hessien ◽

Ahmed El Barbary ◽

Saad el Gendy ◽

Amira Nabil

Keyword(s):

Prostate Cancer ◽

Androgen Receptor ◽

Ligand Binding ◽

Binding Domain ◽

Ligand Binding Domain ◽

Partial Association ◽

Restriction Polymorphism ◽