Grafting of Features of Cystatins C or B into the N-Terminal Region or Second Binding Loop of Cystatin A (Stefin A) Substantially Enhances Inhibition of Cysteine Proteinases†

Biochemistry ◽

10.1021/bi030119v ◽

2003 ◽

Vol 42 (38) ◽

pp. 11326-11333 ◽

Author(s):

Alona Pavlova ◽

Ingemar Björk

Keyword(s):

Terminal Region ◽

Cysteine Proteinases ◽

Stefin A ◽

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The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group

Protein Science ◽

10.1110/ps.9.11.2218 ◽

2000 ◽

Vol 9 (11) ◽

pp. 2218-2224 ◽

Author(s):

Sergio Estrada ◽

Elke Raub-Segall ◽

Ingemar Björk ◽

Steven T. Olson

Keyword(s):

Kinetic Studies ◽

Terminal Region ◽

Fluorescent Reporter ◽

Hairpin Loops ◽

Stefin A ◽

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The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73

European Journal of Biochemistry ◽

10.1046/j.1432-1033.2002.03273.x ◽

2002 ◽

Vol 269 (22) ◽

pp. 5649-5658 ◽

Author(s):

Alona Pavlova ◽

Sergio Estrada ◽

Ingemar Björk

Keyword(s):

Protease Inhibitor ◽

Cysteine Protease ◽

Cysteine Protease Inhibitor ◽

Stefin A ◽

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Hydrophobic sequences can substitute for the wild-type N-terminal sequence of cystatin A (stefin A) in tight binding to cysteine proteinases

European Journal of Biochemistry ◽

10.1046/j.1432-1327.1999.00312.x ◽

1999 ◽

Vol 261 (3) ◽

pp. 682-688 ◽

Author(s):

Karin Ylinenjärvi ◽

Mikael Widersten ◽

Ingemar Björk

Keyword(s):

Tight Binding ◽

Cysteine Proteinases ◽

Wild Type ◽

Terminal Sequence ◽

Stefin A ◽

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The Contribution of N-Terminal Region Residues of Cystatin A (Stefin A) to the Affinity and Kinetics of Inhibition of Papain, Cathepsin B, and Cathepsin L†

Biochemistry ◽

10.1021/bi990003s ◽

1999 ◽

Vol 38 (22) ◽

pp. 7339-7345 ◽

Author(s):

Sergio Estrada ◽

Alla Pavlova ◽

Ingemar Björk

Keyword(s):

Cathepsin B ◽

Cathepsin L ◽

Terminal Region ◽

Stefin A ◽

Kinetics Of ◽

Kinetics Of Inhibition

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Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis

Scientific Reports ◽

10.1038/s41598-019-45805-9 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Anna Mezzapesa ◽

Delphine Bastelica ◽

Lydie Crescence ◽

Marjorie Poggi ◽

Michel Grino ◽

...

Keyword(s):

Cysteine Proteases ◽

Stefin A ◽

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Response of digestive cysteine proteinases from the colorado potato beetle (Leptinotarsa decemlineata) and the black vine weevil (Otiorynchus sulcatus) to a recombinant form of human stefin A

Archives of Insect Biochemistry and Physiology ◽

10.1002/(sici)1520-6327(1996)31:4<451::aid-arch7>3.0.co;2-y ◽

1996 ◽

Vol 31 (4) ◽

pp. 451-464 ◽

Author(s):

Dominique Michaud ◽

Binh Nguyen-Quoc ◽

Thierry C. Vrain ◽

Dunne Fong ◽

Serge Yelle

Keyword(s):

Colorado Potato Beetle ◽

Leptinotarsa Decemlineata ◽

Recombinant Form ◽

Cysteine Proteinases ◽

Potato Beetle ◽

Stefin A ◽

Black Vine Weevil

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The Role of Gly-4 of Human Cystatin A (Stefin A) in the Binding of Target Proteinases. Characterization by Kinetic and Equilibrium Methods of the Interactions of Cystatin A Gly-4 Mutants with Papain, Cathepsin B, and Cathepsin L†

Biochemistry ◽

10.1021/bi980026r ◽

1998 ◽

Vol 37 (20) ◽

pp. 7551-7560 ◽

Author(s):

Sergio Estrada ◽

Maria Nycander ◽

Nikki J. Hill ◽

C. Jeremy Craven ◽

Jonathan P. Waltho ◽

...

Keyword(s):

Cathepsin B ◽

Cathepsin L ◽

Stefin A ◽

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Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinases

FEBS Letters ◽

10.1016/0014-5793(95)00060-m ◽

1995 ◽

Vol 360 (2) ◽

pp. 101-105 ◽

Author(s):

Boris Turk ◽

Anka Ritonja ◽

Ingemar Björk ◽

Veronika Stoka ◽

Iztok Dolenc ◽

...

Keyword(s):

Cysteine Proteinases ◽

Protein Inhibitor ◽

Stefin A ◽

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Human cystatin, a new protein inhibitor of cysteine proteinases

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(84)91073-8 ◽

1984 ◽

Vol 118 (1) ◽

pp. 103-109 ◽

Author(s):

Jože Brzin ◽

Tatjana Popovič ◽

Vito Turk ◽

Ursula Borchart ◽

Werner Machleidt

Keyword(s):

Cysteine Proteinases ◽

Protein Inhibitor ◽

New Protein ◽

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CSTA (cystatin A (stefin A))

Atlas of Genetics and Cytogenetics in Oncology and Haematology ◽

10.4267/2042/44485 ◽

2011 ◽

Author(s):

Z Jevnikar ◽

J Kos

Keyword(s):

Stefin A ◽

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