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17β-estradiol and cathepsins control primordial follicle growth in mouse ovaries

Reproduction ◽  
2021 ◽  
Author(s):  
Kouji Komatsu ◽  
Wei Wei ◽  
Tomohiko Murase ◽  
Satoru Masubuchi
Keyword(s):  
Physiological Mechanism ◽  
Regulatory System ◽  
Primordial Follicle ◽  
Primordial Follicles ◽  
Fetal Bovine Serum Concentration ◽  
Cysteine Cathepsins ◽  
Stefin A ◽  
17Β Estradiol ◽  
Fetal Bovine

This study aimed to clarify the physiological mechanism regulating the growth of primordial follicles in mouse ovaries. In a previous study, we found that increasing the fetal bovine serum concentration in the culture medium promoted the growth of primordial follicles in cultured postnatal day 0 ovaries but not in cultured postnatal day 4 ovaries. Based on these results, we hypothesized that the regulatory system repressing the growth of primordial follicles is established in postnatal day 4 ovaries. To confirm this hypothesis, microarray analysis of postnatal day 0 and 4 ovaries was performed. The results revealed that the expression of mRNA of stefin A homologs increased in postnatal day 4 ovaries. Stefin A belonging to the type 1 cystatin superfamily is an inhibitor of cysteine cathepsins. Consistently, the inhibitor of cathepsins repressed the growth of primordial follicles in cultured postnatal day 0 ovaries. Furthermore, we found that 17β-estradiol promoted the expression of mRNA of stefin A homologs in cultured ovaries and repressed the growth of primordial follicles. Our results demonstrate that 17β-estradiol and cathepsins regulate the growth of primordial follicles in mouse ovaries.

Grass carp (Ctenopharyngodon idella) stefin A: Systematic research on its cloning, expression, characterization and tissue distribution

2021 ◽  
Vol 335 ◽  
pp. 127564
Author(s):  
Ran Li ◽  
Shuhong Li ◽  
Zhiguang Chen ◽  
Yu Jin ◽  
Shulei Li ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Grass Carp ◽  
Ctenopharyngodon Idella ◽  
Systematic Research ◽  
Stefin A ◽  
Grass Carp Ctenopharyngodon Idella ◽  
Expression Characterization

Stefin A-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery

Biochimie ◽  
2019 ◽  
Vol 166 ◽  
pp. 94-102 ◽  
Author(s):  
Andreja Bratovš ◽  
Lovro Kramer ◽  
Georgy Mikhaylov ◽  
Olga Vasiljeva ◽  
Boris Turk
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stefin A ◽  
Targeted Drug

scholarly journals Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Anna Mezzapesa ◽  
Delphine Bastelica ◽  
Lydie Crescence ◽  
Marjorie Poggi ◽  
Michel Grino ◽  
...  
Keyword(s):  
Cysteine Proteases ◽  
Stefin A ◽  
Cystatin A

Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion

2017 ◽  
Vol 243 (4) ◽  
pp. 496-509 ◽  
Author(s):  
Hendrika M Duivenvoorden ◽  
Jai Rautela ◽  
Laura E Edgington-Mitchell ◽  
Alex Spurling ◽  
David W Greening ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Myoepithelial Cell ◽  
Cancer Invasion ◽  
Specific Expression ◽  
Breast Cancer Invasion ◽  
Stefin A

scholarly journals Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma

2016 ◽  
Vol 299 (4) ◽  
pp. 428-438 ◽  
Author(s):  
Yang-Yuan Lin ◽  
Zhi-Wei Chen ◽  
Zhi-Ping Lin ◽  
Li-Bin Lin ◽  
Xue-Ming Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tissue Levels ◽  
Stefin A

Expression of stefin A is of prognostic significance in squamous cell carcinoma of the head and neck

2013 ◽  
Vol 270 (12) ◽  
pp. 3143-3151 ◽  
Author(s):  
Aleksandar Aničin ◽  
Nina Gale ◽  
Lojze Šmid ◽  
Janko Kos ◽  
Primož Strojan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Stefin A

scholarly journals CSTA (cystatin A (stefin A))

2011 ◽  
Author(s):  
Z Jevnikar ◽  
J Kos
Keyword(s):  
Stefin A ◽  
Cystatin A

scholarly journals Structure−function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

2011 ◽  
Vol 24 (9) ◽  
pp. 751-763 ◽  
Author(s):  
Lukas Kurt Josef Stadler ◽  
Toni Hoffmann ◽  
Darren Charles Tomlinson ◽  
Qifeng Song ◽  
Tracy Lee ◽  
...  
Keyword(s):  
Structure Function ◽  
Scaffold Protein ◽  
Stefin A
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