Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis

Scientific Reports ◽

10.1038/s41598-019-45805-9 ◽

2019 ◽

Vol 9 (1) ◽

Author(s):

Anna Mezzapesa ◽

Delphine Bastelica ◽

Lydie Crescence ◽

Marjorie Poggi ◽

Michel Grino ◽

...

Keyword(s):

Cysteine Proteases ◽

Stefin A ◽

Download Full-text

Grafting of Features of Cystatins C or B into the N-Terminal Region or Second Binding Loop of Cystatin A (Stefin A) Substantially Enhances Inhibition of Cysteine Proteinases†

Biochemistry ◽

10.1021/bi030119v ◽

2003 ◽

Vol 42 (38) ◽

pp. 11326-11333 ◽

Author(s):

Alona Pavlova ◽

Ingemar Björk

Keyword(s):

Terminal Region ◽

Cysteine Proteinases ◽

Stefin A ◽

Download Full-text

The N-terminal region of cystatin A (stefin A) binds to papain subsequent to the two hairpin loops of the inhibitor. Demonstration of two-step binding by rapid-kinetic studies of cystatin A labeled at the N-terminus with a fluorescent reporter group

Protein Science ◽

10.1110/ps.9.11.2218 ◽

2000 ◽

Vol 9 (11) ◽

pp. 2218-2224 ◽

Author(s):

Sergio Estrada ◽

Elke Raub-Segall ◽

Ingemar Björk ◽

Steven T. Olson

Keyword(s):

Kinetic Studies ◽

Terminal Region ◽

Fluorescent Reporter ◽

Hairpin Loops ◽

Stefin A ◽

Download Full-text

The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73

European Journal of Biochemistry ◽

10.1046/j.1432-1033.2002.03273.x ◽

2002 ◽

Vol 269 (22) ◽

pp. 5649-5658 ◽

Author(s):

Alona Pavlova ◽

Sergio Estrada ◽

Ingemar Björk

Keyword(s):

Protease Inhibitor ◽

Cysteine Protease ◽

Cysteine Protease Inhibitor ◽

Stefin A ◽

Download Full-text

The Role of Gly-4 of Human Cystatin A (Stefin A) in the Binding of Target Proteinases. Characterization by Kinetic and Equilibrium Methods of the Interactions of Cystatin A Gly-4 Mutants with Papain, Cathepsin B, and Cathepsin L†

Biochemistry ◽

10.1021/bi980026r ◽

1998 ◽

Vol 37 (20) ◽

pp. 7551-7560 ◽

Author(s):

Sergio Estrada ◽

Maria Nycander ◽

Nikki J. Hill ◽

C. Jeremy Craven ◽

Jonathan P. Waltho ◽

...

Keyword(s):

Cathepsin B ◽

Cathepsin L ◽

Stefin A ◽

Download Full-text

CSTA (cystatin A (stefin A))

Atlas of Genetics and Cytogenetics in Oncology and Haematology ◽

10.4267/2042/44485 ◽

2011 ◽

Author(s):

Z Jevnikar ◽

J Kos

Keyword(s):

Stefin A ◽

Download Full-text

Cystatin A protease inhibitor and cysteine proteases in human cervicovaginal fluid in term pregnancy and labor

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2010.10.912 ◽

2011 ◽

Vol 204 (3) ◽

pp. 254.e1-254.e7 ◽

Author(s):

Yujing J. Heng ◽

Megan K.W. Di Quinzio ◽

Michael Permezel ◽

Gregory E. Rice ◽

Harry M. Georgiou

Keyword(s):

Protease Inhibitor ◽

Cysteine Proteases ◽

Term Pregnancy ◽

Cervicovaginal Fluid

Download Full-text

Cystatin, a protein inhibitor of cysteine proteases alters viral protein cleavages in infected human cells

Biochemical and Biophysical Research Communications ◽

10.1016/s0006-291x(85)80054-1 ◽

1985 ◽

Vol 127 (3) ◽

pp. 1072-1076 ◽

Author(s):

Bruce D. Korant ◽

Joze Brzin ◽

Vito Turk

Keyword(s):

Viral Protein ◽

Cysteine Proteases ◽

Human Cells ◽

Protein Inhibitor ◽

Download Full-text

Hydrophobic sequences can substitute for the wild-type N-terminal sequence of cystatin A (stefin A) in tight binding to cysteine proteinases

European Journal of Biochemistry ◽

10.1046/j.1432-1327.1999.00312.x ◽

1999 ◽

Vol 261 (3) ◽

pp. 682-688 ◽

Author(s):

Karin Ylinenjärvi ◽

Mikael Widersten ◽

Ingemar Björk

Keyword(s):

Tight Binding ◽

Cysteine Proteinases ◽

Wild Type ◽

Terminal Sequence ◽

Stefin A ◽

Download Full-text

Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: Biochemical skin barrier against mite cysteine proteases

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2005.03.044 ◽

2005 ◽

Vol 116 (1) ◽

pp. 169-176 ◽

Author(s):

Takeshi Kato ◽

Toshiro Takai ◽

Kouichi Mitsuishi ◽

Ko Okumura ◽

Hideoki Ogawa

Keyword(s):

Skin Barrier ◽

Cysteine Proteases ◽

Der P 1 ◽

Download Full-text

The Contribution of N-Terminal Region Residues of Cystatin A (Stefin A) to the Affinity and Kinetics of Inhibition of Papain, Cathepsin B, and Cathepsin L†

Biochemistry ◽

10.1021/bi990003s ◽

1999 ◽

Vol 38 (22) ◽

pp. 7339-7345 ◽

Author(s):

Sergio Estrada ◽

Alla Pavlova ◽

Ingemar Björk

Keyword(s):

Cathepsin B ◽

Cathepsin L ◽

Terminal Region ◽

Stefin A ◽

Kinetics Of ◽

Kinetics Of Inhibition

Download Full-text