Solution Dynamics and Secondary Structure of Murine Leukemia Inhibitory Factor:  A Four-Helix Cytokine with a Rigid CD Loop†

Biochemistry ◽  
1997 ◽  
Vol 36 (33) ◽  
pp. 10146-10154 ◽  
Author(s):  
Duncan H. Purvis ◽  
Bridget C. Mabbutt
Keyword(s):  
Secondary Structure ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Solution Dynamics ◽  
Murine Leukemia

scholarly journals Identification of CpG island at the 5' end of murine leukemia inhibitory factor gene

FEBS Letters ◽  
1993 ◽  
Vol 319 (1-2) ◽  
pp. 159-162 ◽  
Author(s):  
Petr Kašpar ◽  
Michal Dvořák ◽  
Petr Bartůněk
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Cpg Island ◽  
Inhibitory Factor ◽  
Factor Gene ◽  
Murine Leukemia

scholarly journals Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro

Blood ◽  
1991 ◽  
Vol 77 (10) ◽  
pp. 2150-2153
Author(s):  
D Metcalf ◽  
D Hilton ◽  
NA Nicola
Keyword(s):  
Colony Formation ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Colony Stimulating Factor ◽  
Interleukin 3 ◽  
Stimulating Factor ◽  
Murine Leukemia

Receptors for murine leukemia inhibitory factor (LIF) were demonstrated on immature and mature murine megakaryocytes. LIF alone had no effects in culture on the survival or proliferation of normal murine megakaryocytes or their precursors. However, combination of LIF with multipotential-colony-stimulating factor (Multi-CSF) (interleukin-3) enhanced the megakaryocyte colony formation able to be stimulated by Multi-CSF; the enhancement involved all types of megakaryocyte colony and resulted in the formation of increased numbers of megakaryocytes. These observations provide a possible basis for the observation that, when LIF is injected in vivo, elevations are observed in megakaryocyte numbers and platelet levels.

scholarly journals Molecular Basis of the Soluble and Membrane-bound Forms of the Murine Leukemia Inhibitory Factor Receptor -Chain

1996 ◽  
Vol 271 (10) ◽  
pp. 5495-5504 ◽  
Author(s):  
Catherine M. Owczarek ◽  
Meredith J. Layton ◽  
Lorraine G. Robb ◽  
Nicos A. Nicola ◽  
C. Glenn Begley
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Molecular Basis ◽  
Inhibitory Factor ◽  
Leukemia Inhibitory Factor Receptor ◽  
Receptor Chain ◽  
Membrane Bound ◽  
Murine Leukemia

scholarly journals Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro

Blood ◽  
1991 ◽  
Vol 77 (10) ◽  
pp. 2150-2153 ◽  
Author(s):  
D Metcalf ◽  
D Hilton ◽  
NA Nicola
Keyword(s):  
Colony Formation ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Colony Stimulating Factor ◽  
Interleukin 3 ◽  
Stimulating Factor ◽  
Murine Leukemia

Abstract Receptors for murine leukemia inhibitory factor (LIF) were demonstrated on immature and mature murine megakaryocytes. LIF alone had no effects in culture on the survival or proliferation of normal murine megakaryocytes or their precursors. However, combination of LIF with multipotential-colony-stimulating factor (Multi-CSF) (interleukin-3) enhanced the megakaryocyte colony formation able to be stimulated by Multi-CSF; the enhancement involved all types of megakaryocyte colony and resulted in the formation of increased numbers of megakaryocytes. These observations provide a possible basis for the observation that, when LIF is injected in vivo, elevations are observed in megakaryocyte numbers and platelet levels.

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