Xenobiotic Adduct Formation with DNA or Glutathione

1985 ◽  
pp. 97-110
Author(s):  
M. RAHIMTULA ◽  
W. MARSHALL ◽  
B. GREGORY ◽  
P. J. O'BRIEN
Keyword(s):  
Adduct Formation

Addition of Tetrachloromethane to 1,5-Hexadiene

1992 ◽  
Vol 57 (2) ◽  
pp. 393-396 ◽  
Author(s):  
Martin Kotora ◽  
Milan Hájek
Keyword(s):  
Palladium Catalyst ◽  
Adduct Formation ◽  
High Yield ◽  
Reaction Conditions ◽  
Dibenzoyl Peroxide

The 2 : 1 adduct as the final product of the addition of tetrachloromethane to 1,5-hexadiene catalyzed by copper(I)-butylamine complex was obtained in high yield (96%) under mild reaction conditions. Predominant 1 : 1 adduct formation was observed in the presence of a palladium catalyst or dibenzoyl peroxide initiator.

Formation of spiro adduct from N-methyl-N-(2,4,6-trinitrophenyl)glycine anion

1989 ◽  
Vol 54 (2) ◽  
pp. 440-445 ◽  
Author(s):  
Vladimír Macháček ◽  
Alexandr Čegan ◽  
Miloš Sedlák ◽  
Vojeslav Štěrba
Keyword(s):  
Nmr Spectroscopy ◽  
Dimethyl Sulfoxide ◽  
Equilibrium Constant ◽  
Mole Fraction ◽  
Nucleophilic Addition ◽  
Adduct Formation ◽  
First Case ◽  
C Nmr

The intramolecular nucleophilic addition of N-methyl-N-(2,4,6-trinitrophenyl)glycine anion in methanol-dimethyl sulfoxide mixtures produces spiro[(3-methyl-5-oxazolidinone)-2,1'-(2',4',6'-trinitrobenzenide)]. The spiro adduct has been identified by means of 1H and 13C NMR spectroscopy. This is the first case when the formation of a Meisenheimer adduct with carboxylate ion is observed. Logarithm of the equilibrium constant of adduct formation increases linearly with the mole fraction of dimethyl sulfoxide in its mixture with methanol.

Probing the Paradigm of Promiscuity for N‐Heterocyclic Carbene Complexes and their Protein Adduct Formation

2021 ◽  
Author(s):  
Matthew P. Sullivan ◽  
Monika Cziferszky ◽  
Iogann Tolbatov ◽  
Dianna Truong ◽  
Davide Mercadante ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Carbene Complexes ◽  
Protein Adduct

Probing the Paradigm of Promiscuity for N‐Heterocyclic Carbene Complexes and their Protein Adduct Formation

2021 ◽  
Author(s):  
Matthew P. Sullivan ◽  
Monika Cziferszky ◽  
Iogann Tolbatov ◽  
Dianna Truong ◽  
Davide Mercadante ◽  
...  
Keyword(s):  
Adduct Formation ◽  
Carbene Complexes ◽  
Protein Adduct

Nitroreduction of 4-Nitropyrene Is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats

1999 ◽  
Vol 12 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Young-Heum Chae ◽  
Ben-Yi Ji ◽  
Jyh-Ming Lin ◽  
Peter P. Fu ◽  
Bongsup P. Cho ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct
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