Multiple Interaction Regions in the Orthosteric Ligand Binding Domain of the α7 Neuronal Nicotinic Acetylcholine Receptor

Journal of Chemical Information and Modeling ◽

10.1021/ci3001953 ◽

2012 ◽

Vol 52 (11) ◽

pp. 3064-3073 ◽

Author(s):

Yunde Xiao ◽

Philip S. Hammond ◽

Anatoly A. Mazurov ◽

Daniel Yohannes

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Interaction Regions ◽

Multiple Interaction

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Structural Evaluation of Distant Homology. A 3-D Model of the Ligand Binding Domain of the Nicotinic Acetylcholine Receptor Based on Acetylcholinesterase: Consistency with Experimental Data

Journal of Molecular Modeling ◽

10.1007/s0089460020046 ◽

1996 ◽

Vol 2 (3) ◽

pp. 46-50 ◽

Author(s):

Ajita A. Bhat ◽

E. Will Taylor

Keyword(s):

Experimental Data ◽

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Nicotinic Acetylcholine ◽

Structural Evaluation ◽

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Structural Evaluation of Distant Homology. A 3-D Model of the Ligand Binding Domain of the Nicotinic Acetylcholine Receptor Based on Acetylcholinesterase: Consistency with Experimental Data

Journal of Molecular Modeling ◽

10.1007/s008940050019 ◽

1996 ◽

Vol 2 (3-4) ◽

pp. 46-50 ◽

Author(s):

Ajita A. Bhat ◽

E. Will Taylor

Keyword(s):

Experimental Data ◽

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Nicotinic Acetylcholine ◽

Structural Evaluation ◽

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The 2.7 Å Structure of AChBP, Homologue of the Ligand-Binding Domain of the Nicotinic Acetylcholine Receptor

Ion Channels: From Atomic Resolution Physiology to Functional Genomics - Novartis Foundation Symposia ◽

10.1002/0470868759.ch3 ◽

2008 ◽

pp. 22-32 ◽

Author(s):

Katjuša Brejc ◽

Willem J. van Dijk ◽

August B. Smit ◽

Titia K. Sixma

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Nicotinic Acetylcholine

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Potentials of Mean Force for Acetylcholine Unbinding from the Alpha7 Nicotinic Acetylcholine Receptor Ligand-Binding Domain

Journal of the American Chemical Society ◽

10.1021/ja057292u ◽

2006 ◽

Vol 128 (9) ◽

pp. 3019-3026 ◽

Author(s):

Deqiang Zhang ◽

Justin Gullingsrud ◽

J. Andrew McCammon

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Potentials Of Mean Force

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Potentials of Mean Force for Acetylcholine Unbinding from the Alpha7 Nicotinic Acetylcholine Receptor Ligand-Binding Domain [J. Am. Chem. Soc.2006,128, 3019−3026].

Journal of the American Chemical Society ◽

10.1021/ja069959y ◽

2006 ◽

Vol 128 (13) ◽

pp. 4493-4493 ◽

Author(s):

Deqiang Zhang ◽

J. Andrew McCammon

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Potentials Of Mean Force

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Structure and Function of AChBP, Homologue of the Ligand-Binding Domain of the Nicotinic Acetylcholine Receptor

Annals of the New York Academy of Sciences ◽

10.1196/annals.1254.010 ◽

2003 ◽

Vol 998 (1) ◽

pp. 81-92 ◽

Author(s):

AUGUST B. SMIT ◽

KATJUŠA BREJC ◽

NAWEED SYED ◽

TITIA K. SIXMA

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Structure And Function ◽

Binding Domain ◽

Ligand Binding Domain ◽

Nicotinic Acetylcholine ◽

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The ligand binding domain of the nicotinic acetylcholine receptor

FEBS Letters ◽

10.1016/0014-5793(93)80525-y ◽

1993 ◽

Vol 318 (3) ◽

pp. 264-268 ◽

Author(s):

Sylvia G. Kachalsky ◽

Mirit Aladjem ◽

Dora Barchan ◽

Sara Fuchs

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Nicotinic Acetylcholine

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Freeze‐Frame Click‐Chemistry Synthesis on a Soluble Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR) Ligand Binding Domain

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.1127.5 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Akos Nemecz ◽

Todd Talley ◽

Joseph Fotsing ◽

Timo Weide ◽

Neil Grimster ◽

...

Keyword(s):

Ligand Binding ◽

Click Chemistry ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Nicotinic Acetylcholine ◽

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Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper

Neuropharmacology ◽

10.1016/j.neuropharm.2010.07.014 ◽

2011 ◽

Vol 60 (1) ◽

pp. 159-171 ◽

Author(s):

Roger L. Papke ◽

Clare Stokes ◽

Dustin K. Williams ◽

Jingyi Wang ◽

Nicole A. Horenstein

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Accessibility Analysis

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Rat α3/β4 Subtype of Neuronal Nicotinic Acetylcholine Receptor Stably Expressed in a Transfected Cell Line: Pharmacology of Ligand Binding and Function

Molecular Pharmacology ◽

10.1124/mol.54.2.322 ◽

1998 ◽

Vol 54 (2) ◽

pp. 322-333 ◽

Author(s):

Yingxian Xiao ◽

Erin L. Meyer ◽

Jessica M. Thompson ◽

Alexander Surin ◽

Jarda Wroblewski ◽

...

Keyword(s):

Ligand Binding ◽

Cell Line ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Transfected Cell Line ◽

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