Rates of complex formation reactions of hexa(dimethyl sulfoxide)nickel(II). Five-coordinate intermediate problem

1970 ◽  
Vol 9 (10) ◽  
pp. 2346-2350 ◽  
Author(s):  
Cooper H. Langford ◽  
Hon Gee Tsiang
Keyword(s):  
Complex Formation ◽  
Dimethyl Sulfoxide ◽  
Intermediate Problem

Thermodynamic and spectroscopic studies on silver(I) complex formation with phosphorus multidentate ligands in dimethyl sulfoxide

1990 ◽  
Vol 29 (15) ◽  
pp. 2859-2862 ◽  
Author(s):  
Plinio Di Bernardo ◽  
Giuliano Dolcetti ◽  
Roberto Portanova ◽  
Marilena Tolazzi ◽  
Giuliana Tomat ◽  
...  
Keyword(s):  
Complex Formation ◽  
Dimethyl Sulfoxide ◽  
Spectroscopic Studies ◽  
Multidentate Ligands

scholarly journals Weak Interaction of the Antimetabolite Drug Methotrexate with a Cavitand Derivative

2020 ◽  
Vol 21 (12) ◽  
pp. 4345
Author(s):  
Zsolt Preisz ◽  
Zoltán Nagymihály ◽  
Beáta Lemli ◽  
László Kollár ◽  
Sándor Kunsági-Máté
Keyword(s):  
Molecular Modeling ◽  
Complex Formation ◽  
Dimethyl Sulfoxide ◽  
Closed Form ◽  
Gas Phase ◽  
Inclusion Complexes ◽  
Weak Interaction ◽  
Temperature Range ◽  
Higher Temperature ◽  
Lower Temperature

Formation of inclusion complexes involving a cavitand derivative (as host) and an antimetabolite drug, methotrexate (as guest) was investigated by photoluminescence measurements in dimethyl sulfoxide solvent. Molecular modeling performed in gas phase reflects that, due to the structural reasons, the cavitand can include the methotrexate in two forms: either by its opened structure with free androsta-4-en-3-one-17α-ethinyl arms or by the closed form when all the androsta-4-en-3-one-17α-ethinyl arms play role in the complex formation. Experiments reflect enthalpy driven complex formation in higher temperature range while at lower temperature the complexes are stabilized by the entropy gain.

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