Pulse and continuous radiolysis of cyano-bridged polynuclear ruthenium complexes in aqueous solution

Ruthenium complexes have stood out by several mononuclear complexes which have entered into clinical trials, such as imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) and ([Ru(II)(4,4'-dimethyl-2,2'-bipyridine)2-(2(2'-,2'':5'',2'''-terthiophene)-imidazo[4,5-f] [1,10]phenanthroline)] 2+) (TLD-1433), opening a new avenue for developing promising ruthenium-based anticancer drugs alternative to Cisplatin. Polynuclear ruthenium complexes were reported to exhibit synergistic and/or complementary effects: the enhanced DNA structural recognition and DNA binding as well as in vitro anticancer activities. This review overviews some representative polynuclear ruthenium complexes acting as DNA structural probes, DNA binders and in vitro anticancer agents, which were developed during last decades. These complexes are reviewed according to two main categories of homo-polynuclear and hetero-polynuclear complexes, each of which is further clarified into the metal centers linked by rigid and flexible bridging ligands. The perspective, challenges and future efforts for investigations into these exciting complexes are pointed out or suggested.

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Rod-like Dinuclear Ruthenium Complexes for Dye-sensitized Photovoltaics

MRS Proceedings ◽

10.1557/proc-708-bb10.38 ◽

2001 ◽

Vol 708 ◽

Author(s):

Ravi Mosurkal ◽

Jin-An He ◽

Jayant Kumar ◽

Lian Li ◽

John Walker ◽

...

Keyword(s):

Photovoltaic Cells ◽

Ruthenium Complexes ◽

Liquid Electrolyte ◽

Photovoltaic Properties ◽

Dye Sensitized ◽

Dinuclear Ruthenium ◽

Rigid Rod ◽

Terpyridine Ligands ◽

Polynuclear Ruthenium Complexes ◽

Dinuclear Ruthenium Complexes

ABSTRACTRuthenium complexes with tridentate terpyridine type ligands have many structural advantages over the complexes with bipyridine ligands. Polynuclear ruthenium complexes prepared using these terpyridine ligands bridged with phenylene rings are potential candidates for photosensitization in dye-sensitized photovoltaic cells. In this study, we have carried out synthesis, characterization and theoretical modeling of rigid, rod-like homometallic dinuclear ruthenium complexes using terpyridine and bipyridine ligands. The photophysical and photovoltaic properties have been investigated. These supramolecular dyes are found to be efficient photosensitizers in dye-sensitized photovoltaic cells when a liquid electrolyte is employed.

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Studies of Ruthenium Complexes. III. Kinetics of Isotopic Ligand-Exchange Reactions of Halogenopentaammineruthenium(III) Complexes in Aqueous Solution

Bulletin of the Chemical Society of Japan ◽

10.1246/bcsj.45.3081 ◽

1972 ◽

Vol 45 (10) ◽

pp. 3081-3083 ◽

Cited By ~ 2

Author(s):

Tetsuo Shinohara ◽

Takato Yamada ◽

Noriyuki Takebayashi ◽

Shun-ichi Hiraki ◽

Akira Ohyoshi

Keyword(s):

Aqueous Solution ◽

Ligand Exchange ◽

Ruthenium Complexes ◽

Exchange Reactions ◽

Kinetics Of

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Catalytic hydrogenation of carbonyl and nitro compounds using an [N,O]-chelate half-sandwich ruthenium catalyst

Dalton Transactions ◽

10.1039/c8dt02677g ◽

2019 ◽

Vol 48 (21) ◽

pp. 7158-7166 ◽

Cited By ~ 6

Author(s):

Zi-Jian Yao ◽

Jing-Wei Zhu ◽

Nan Lin ◽

Xin-Chao Qiao ◽

Wei Deng

Keyword(s):

Aqueous Solution ◽

High Activity ◽

Catalytic Hydrogenation ◽

Ruthenium Complexes ◽

Nitro Compounds ◽

Ruthenium Catalyst ◽

Half Sandwich

A series of N,O-chelate half-sandwich ruthenium complexes have been synthesized, which exhibited high activity for the catalytic hydrogenation of carbonyl and nitro compounds in aqueous solution.

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Decomposition of Hydrogen Peroxide Catalysed by Ruthenium complexes

Australian Journal of Chemistry ◽

10.1071/ch9590138 ◽

1959 ◽

Vol 12 (2) ◽

pp. 138 ◽

Cited By ~ 4

Author(s):

FP Dwyer ◽

NK King ◽

ME Winfield

Keyword(s):

Aqueous Solution ◽

Hydrogen Peroxide ◽

Ruthenium Complexes ◽

Hydrogen Ions ◽

Kinetic Measurements ◽

H2o2 Decomposition ◽

Electrolytic Oxidation ◽

Preliminary Study ◽

Electron Reduction

A preliminary study has been made of the oxidation of four octahedral RuII complexes in aqueous solution, particularly by H2O2. Kinetic measurements and simple experiments such as electrolytic oxidation followed by reduction with H2O2 have been used to obtain evidence for the mechanism of H2O2 decomposition when catalysed by the ruthenium complexes. The main course of the catalysis appears to consist in oxidation of RuII to RuIV with a corresponding reduction of H2O2 to hydroxyl ions, followed by a "electron reduction of RuIV to RuII with oxidation of H2O2 to O2 and hydrogen ions.

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Hydrogen activation by arene ruthenium complexes in aqueous solution. Part 2. Build-up of cationic tri- and tetra-nuclear ruthenium clusters with hydrido ligands

Journal of the Chemical Society Dalton Transactions ◽

10.1039/dt9940003215 ◽

1994 ◽

pp. 3215-3223 ◽

Cited By ~ 49

Author(s):

Götz Meister ◽

Gerd Rheinwald ◽

Helen Stoeckli-Evans ◽

Georg Süss-Fink

Keyword(s):

Aqueous Solution ◽

Ruthenium Complexes ◽

Hydrogen Activation ◽

Ruthenium Clusters

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Hydrolytic behaviour of mono- and dithiolato-bridged dinuclear arene ruthenium complexes and their interactions with biological ligands

RSC Advances ◽

10.1039/c6ra07701c ◽

2016 ◽

Vol 6 (44) ◽

pp. 38332-38341 ◽

Cited By ~ 5

Author(s):

David Stíbal ◽

Lennart Geiser ◽

Georg Süss-Fink ◽

Julien Furrer

Keyword(s):

Aqueous Solution ◽

Ruthenium Complexes

Compared to the inert and highly cytotoxic dinuclear p-cymene ruthenium trithiolato complexes, the less cytotoxic mono- and dithiolato complexes readily hydrolyse in aqueous solution and form adducts with cysteine, but do not interact with DNA.

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