half sandwich
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Asma Nahaei ◽  
Zeinab Mandegani ◽  
Samira Chamyani ◽  
Masood Fereidoonnezhad ◽  
Hamid R. Shahsavari ◽  

2022 ◽  
Vol 23 (2) ◽  
pp. 813
István Kacsir ◽  
Adrienn Sipos ◽  
Attila Bényei ◽  
Eszter Janka ◽  
Péter Buglyó ◽  

Platinum complexes are used in chemotherapy, primarily as antineoplastic agents. In this study, we assessed the cytotoxic and cytostatic properties of a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich-type complexes with bidentate monosaccharide ligands. We identified 5 compounds with moderate to negligible acute cytotoxicity but with potent long-term cytostatic activity. These structure-activity relationship studies revealed that: 1) osmium(II) p-cymene complexes were active in all models, while rhodium(III) and iridium(III) Cp* complexes proved largely inactive; 2) the biological effect was influenced by the nature of the central azole ring of the ligands—1,2,3-triazole was the most effective, followed by 1,3,4-oxadiazole, while the isomeric 1,2,4-oxadiazole abolished the cytostatic activity; 3) we found a correlation between the hydrophobic character of the complexes and their cytostatic activity: compounds with O-benzoyl protective groups on the carbohydrate moiety were active, compared to O-deprotected ones. The best compound, an osmium(II) complex, had an IC50 value of 0.70 µM. Furthermore, the steepness of the inhibitory curve of the active complexes suggested cooperative binding; cooperative molecules were better inhibitors than non-cooperative ones. The cytostatic activity of the active complexes was abolished by a lipid-soluble antioxidant, vitamin E, suggesting that oxidative stress plays a major role in the biological activity of the complexes. The complexes were active on ovarian cancer, pancreatic adenocarcinoma, osteosarcoma and Hodgkin’s lymphoma cells, but were inactive on primary, non-transformed human fibroblasts, indicating their applicability as potential anticancer agents.

2022 ◽  
Julijan Sarcevic ◽  
Tobias Heitkemper ◽  
Christian P. Sindlinger

The synthesis and initial observations regarding the reactivity of borole-based half-sandwich complexes with apical divalent group 14 elements germanium and tin are described.

Zakaria Moutaoukil ◽  
Emmanuel Serrano-Diez ◽  
I. Gonzalez Collado ◽  
Manuel Jimenez-Tenorio ◽  
José Manuel Botubol-Ares

An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides has been developed employing novel pentamethylcyclopentadienylruthenium (II) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The acetonitrile complex 2 has proven...

2022 ◽  
Vol 517 ◽  
pp. 112050
Jingyi Wang ◽  
Chengyu Liu ◽  
Liming Cao ◽  
Yan Xiong ◽  
Jinxing Ye ◽  

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