Pyrrolo[2,3-d]pyrimidine nucleoside antibiotics. Total synthesis and structure of toyocamycin, unamycin B, vengicide, antibiotic E-212, and sangivamycin (BA-90912)

1968 ◽  
Vol 90 (2) ◽  
pp. 524-526 ◽  
Author(s):  
Richard L. Tolman ◽  
Roland K. Robins ◽  
Leroy B. Townsend
Keyword(s):  
Total Synthesis ◽  
Pyrimidine Nucleoside ◽  
Nucleoside Antibiotics

Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics

2021 ◽  
Author(s):  
M. McErlean ◽  
X. Liu ◽  
Z. Cui ◽  
B. Gust ◽  
S. G. Van Lanen
Keyword(s):  
Partial Characterization ◽  
Pyrimidine Nucleoside ◽  
Functional Assignment ◽  
Nucleoside Antibiotics ◽  
Identification And Characterization

This review highlights the functional assignment and partial characterization of multiple proteins involved in the biosynthesis of structurally complex pyrimidine-derived nucleoside antibiotics.

scholarly journals A total synthesis of the naturally occurring pyrrolo[2,3-]pyrimidine nucleoside, mycalisine A

1988 ◽  
Vol 29 (33) ◽  
pp. 4073-4076 ◽  
Author(s):  
Eric A. Meade ◽  
Steven H. Krawczyk ◽  
Leroy B. Townsend*
Keyword(s):  
Total Synthesis ◽  
Pyrimidine Nucleoside ◽  
Naturally Occurring

Thieme Chemistry Journals Awardees – Where Are They Now? ­Ribosylation of an Acid-Labile Glycosyl Acceptor as a Potential Key Step for the Synthesis of Nucleoside Antibiotics

Synlett ◽  
2017 ◽  
Vol 29 (04) ◽  
pp. 440-446 ◽  
Author(s):  
Christian Ducho ◽  
Daniel Wiegmann ◽  
Anatol Spork ◽  
Giuliana Niro
Keyword(s):  
Total Synthesis ◽  
Antibacterial Agents ◽  
Protecting Group ◽  
Nucleoside Antibiotics ◽  
Naturally Occurring ◽  
Efficient Construction ◽  
Pentenyl Glycosides ◽  
Acid Labile

Naturally occurring nucleoside antibiotics (e.g., muraymycins and caprazamycins) represent attractive lead structures for the development of urgently needed novel antibacterial agents. One major challenge in the total synthesis of muraymycins, caprazamycins, and their analogues is the efficient construction of the densely functionalized aminoribosylated uridine-derived core unit. In order to avoid tedious protecting-group manipulations, we have aimed to conduct the aminoribosylation step with an acid-labile glycosyl acceptor. Therefore, different glycosylation approaches have been studied, with pentenyl glycosides giving the best results.

Total Synthesis of Nucleoside Antibiotics Plicacetin and Streptcytosine A

2018 ◽  
Vol 83 (13) ◽  
pp. 7076-7084 ◽  
Author(s):  
Jiqiang Fu ◽  
Stephane Laval ◽  
Biao Yu
Keyword(s):  
Total Synthesis ◽  
Nucleoside Antibiotics

Synthesis, cytotoxicity, and antiviral activity of some acyclic analogs of the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin

1989 ◽  
Vol 32 (2) ◽  
pp. 402-408 ◽  
Author(s):  
Pranab K. Gupta ◽  
Sylvia Daunert ◽  
M. Reza Nassiri ◽  
Linda L. Wotring ◽  
John C. Drach ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Pyrimidine Nucleoside ◽  
Nucleoside Antibiotics
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