How Does Product Isotope Effect Prove the Operation of a Two-State “Rebound” Mechanism in C−H Hydroxylation by Cytochrome P450?

2003 ◽  
Vol 125 (43) ◽  
pp. 13024-13025 ◽  
Author(s):  
Devesh Kumar ◽  
Samuël P. de Visser ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Product Isotope

A New Mechanistic Probe for Cytochrome P450:  An Application of Isotope Effect Profiles

1997 ◽  
Vol 119 (21) ◽  
pp. 5069-5070 ◽  
Author(s):  
John I. Manchester ◽  
Joseph P. Dinnocenzo ◽  
Higgins ◽  
Jeffrey P. Jones
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Mechanistic Probe

Oxidation of Tertiary Amines by Cytochrome P450-Kinetic Isotope Effect as a Spin-State Reactivity Probe

2009 ◽  
Vol 15 (34) ◽  
pp. 8492-8503 ◽  
Author(s):  
Chunsen Li ◽  
Wei Wu ◽  
Kyung-Bin Cho ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Spin State ◽  
Kinetic Isotope Effect ◽  
Tertiary Amines ◽  
Kinetic Isotope

Intramolecular Isotope Effects for Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl by Cytochrome P450:  Relationship between Distance of Methyl Groups and Masking of the Intrinsic Isotope Effect†

Biochemistry ◽  
1997 ◽  
Vol 36 (23) ◽  
pp. 7136-7143 ◽  
Author(s):  
Krishna R. Iyer ◽  
Jeffrey P. Jones ◽  
John F. Darbyshire ◽  
William F. Trager
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Isotope Effects ◽  
Methyl Groups ◽  
Benzylic Hydroxylation

Isotope Effect Studies on the Cytochrome P450 Enzymes

1995 ◽  
Vol 27 (1-2) ◽  
pp. 45-59 ◽  
Author(s):  
Kenneth r. Korzekwa ◽  
James r. Gillette ◽  
William f. Trager
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Cytochrome P450 Enzymes

Kinetic Isotope Effect is a Sensitive Probe of Spin State Reactivity in C−H Hydroxylation ofN,N-Dimethylaniline by Cytochrome P450

2006 ◽  
Vol 128 (2) ◽  
pp. 394-395 ◽  
Author(s):  
Chunsen Li ◽  
Wei Wu ◽  
Devesh Kumar ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Spin State ◽  
Kinetic Isotope Effect ◽  
Kinetic Isotope

Theoretical Study ofN-Demethylation of SubstitutedN,N-Dimethylanilines by Cytochrome P450:  The Mechanistic Significance of Kinetic Isotope Effect Profiles

2007 ◽  
Vol 111 (26) ◽  
pp. 7700-7710 ◽  
Author(s):  
Yong Wang ◽  
Devesh Kumar ◽  
Chuanlu Yang ◽  
Keli Han ◽  
Sason Shaik
Keyword(s):  
Cytochrome P450 ◽  
Isotope Effect ◽  
Kinetic Isotope Effect ◽  
Theoretical Study ◽  
Kinetic Isotope
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