Practical Route to Relative Diffusion Coefficients and Electronic Relaxation Rates of Paramagnetic Metal Complexes in Solution by Model-Independent Outer-Sphere NMRD. Potentiality for MRI Contrast Agents

2005 ◽  
Vol 127 (45) ◽  
pp. 15801-15814 ◽  
Author(s):  
Pascal H. Fries ◽  
Christelle Gateau ◽  
Marinella Mazzanti
Keyword(s):  
Metal Complexes ◽  
Contrast Agents ◽  
Diffusion Coefficients ◽  
Outer Sphere ◽  
Mri Contrast Agents ◽  
Electronic Relaxation ◽  
Relaxation Rates ◽  
Mri Contrast ◽  
Paramagnetic Metal ◽  
Model Independent

Silver(I) and rhenium(I) metal complexes of a 2,2′-bipyridine-functionalized third-generation tris(pyrazolyl)methane ligand

2016 ◽  
Vol 72 (11) ◽  
pp. 826-831 ◽  
Author(s):  
Radu F. Semeniuc ◽  
Daniel L. Reger ◽  
Mark D. Smith
Keyword(s):  
Biological Activity ◽  
Coordination Polymer ◽  
Metal Complexes ◽  
Contrast Agents ◽  
Coordination Mode ◽  
Mri Contrast Agents ◽  
Third Generation ◽  
Supramolecular Systems ◽  
Mri Contrast ◽  
One Dimensional

Heterotopic ligands offer the possibility of preparing polynuclear bimetallic complexes. Recent studies of heteroditopic ligands and their metal complexes have focused on novel supramolecular systems, biological activity, and the development of MRI contrast agents. The heteroditopic ligand Bipy–CH2–O–CH2–C(pz)3(Bipy-L; Bipy is 2,2′-bipyridine and pz is pyrazolyl) reacts with AgBF4to produce the coordination polymercatena-poly[[silver(I)-(μ-5-{[tris(pyrazol-1-yl)methoxy]methyl-κ2N,N′}-2,2′-bipyridine-κ2N,N′)] diethyl ether hemisolvate], {[Ag(C22H20N8O)]BF4·0.5C4H10O}n, and with Re(CO)5Br to form the discrete compound bromidotricarbonyl(5-{[tris(pyrazol-1-yl)methoxy]methyl}-2,2′-bipyridine-κ2N,N′)rhenium(I), [ReBr(C22H20N8O)(CO)3]. The silver(I) compound is a one-dimensional coordination polymer, built up by a κ2coordination mode of the bipyridine group and a κ2–κ0coordination mode of the –C(pz)3donor set. In [ReBr(Bipy-L)(CO)3], the ligand coordinates onlyviathe bipyridine end, leaving the –C(pz)3donor set free for further coordination interactions.

scholarly journals Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

2020 ◽  
Vol 13 (10) ◽  
pp. 268 ◽  
Author(s):  
Pooyan Khalighinejad ◽  
Daniel Parrott ◽  
A. Dean Sherry
Keyword(s):  
Contrast Agents ◽  
Metal Ion ◽  
Relaxation Times ◽  
Essential Element ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Mr Contrast Agents ◽  
Wide Range ◽  
Paramagnetic Metal

Paramagnetic metal ion complexes, mostly based on gadolinium (Gd3+), have been used for over 30 years as magnetic resonance imaging (MRI) contrast agents. Gd3+-based contrast agents have a strong influence on T1 relaxation times and are consequently the most commonly used agents in both the clinical and research environments. Zinc is an essential element involved with over 3000 different cellular proteins, and disturbances in tissue levels of zinc have been linked to a wide range of pathologies, including Alzheimer’s disease, prostate cancer, and diabetes mellitus. MR contrast agents that respond to the presence of Zn2+ in vivo offer the possibility of imaging changes in Zn2+ levels in real-time with the superior spatial resolution offered by MRI. Such responsive agents, often referred to as smart agents, are typically composed of a paramagnetic metal ion with a ligand encapsulating it and one or more chelating units that selectively bind with the analyte of interest. Translation of these agents into clinical radiology is the next goal. In this review, we discuss Gd3+-based MR contrast agents that respond to a change in local Zn2+ concentration.

Diffusion coefficients of articular cartilage for different CT and MRI contrast agents

2010 ◽  
Vol 32 (8) ◽  
pp. 878-882 ◽  
Author(s):  
K.A.M. Kulmala ◽  
R.K. Korhonen ◽  
P. Julkunen ◽  
J.S. Jurvelin ◽  
T.M. Quinn ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Contrast Agents ◽  
Diffusion Coefficients ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Ct And Mri
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