Relative diffusion of paramagnetic metal complexes of MRI contrast agents in an isotropic hydrogel medium

2016 ◽  
Vol 10 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Bimali Sanjeevani Weerakoon ◽  
Toshiaki Osuga
Keyword(s):  
Metal Complexes ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Relative Diffusion ◽  
Paramagnetic Metal

Silver(I) and rhenium(I) metal complexes of a 2,2′-bipyridine-functionalized third-generation tris(pyrazolyl)methane ligand

2016 ◽  
Vol 72 (11) ◽  
pp. 826-831 ◽  
Author(s):  
Radu F. Semeniuc ◽  
Daniel L. Reger ◽  
Mark D. Smith
Keyword(s):  
Biological Activity ◽  
Coordination Polymer ◽  
Metal Complexes ◽  
Contrast Agents ◽  
Coordination Mode ◽  
Mri Contrast Agents ◽  
Third Generation ◽  
Supramolecular Systems ◽  
Mri Contrast ◽  
One Dimensional

Heterotopic ligands offer the possibility of preparing polynuclear bimetallic complexes. Recent studies of heteroditopic ligands and their metal complexes have focused on novel supramolecular systems, biological activity, and the development of MRI contrast agents. The heteroditopic ligand Bipy–CH2–O–CH2–C(pz)3(Bipy-L; Bipy is 2,2′-bipyridine and pz is pyrazolyl) reacts with AgBF4to produce the coordination polymercatena-poly[[silver(I)-(μ-5-{[tris(pyrazol-1-yl)methoxy]methyl-κ2N,N′}-2,2′-bipyridine-κ2N,N′)] diethyl ether hemisolvate], {[Ag(C22H20N8O)]BF4·0.5C4H10O}n, and with Re(CO)5Br to form the discrete compound bromidotricarbonyl(5-{[tris(pyrazol-1-yl)methoxy]methyl}-2,2′-bipyridine-κ2N,N′)rhenium(I), [ReBr(C22H20N8O)(CO)3]. The silver(I) compound is a one-dimensional coordination polymer, built up by a κ2coordination mode of the bipyridine group and a κ2–κ0coordination mode of the –C(pz)3donor set. In [ReBr(Bipy-L)(CO)3], the ligand coordinates onlyviathe bipyridine end, leaving the –C(pz)3donor set free for further coordination interactions.

scholarly journals Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents

2020 ◽  
Vol 13 (10) ◽  
pp. 268 ◽  
Author(s):  
Pooyan Khalighinejad ◽  
Daniel Parrott ◽  
A. Dean Sherry
Keyword(s):  
Contrast Agents ◽  
Metal Ion ◽  
Relaxation Times ◽  
Essential Element ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Mr Contrast Agents ◽  
Wide Range ◽  
Paramagnetic Metal

Paramagnetic metal ion complexes, mostly based on gadolinium (Gd3+), have been used for over 30 years as magnetic resonance imaging (MRI) contrast agents. Gd3+-based contrast agents have a strong influence on T1 relaxation times and are consequently the most commonly used agents in both the clinical and research environments. Zinc is an essential element involved with over 3000 different cellular proteins, and disturbances in tissue levels of zinc have been linked to a wide range of pathologies, including Alzheimer’s disease, prostate cancer, and diabetes mellitus. MR contrast agents that respond to the presence of Zn2+ in vivo offer the possibility of imaging changes in Zn2+ levels in real-time with the superior spatial resolution offered by MRI. Such responsive agents, often referred to as smart agents, are typically composed of a paramagnetic metal ion with a ligand encapsulating it and one or more chelating units that selectively bind with the analyte of interest. Translation of these agents into clinical radiology is the next goal. In this review, we discuss Gd3+-based MR contrast agents that respond to a change in local Zn2+ concentration.

Cubosomes as Carriers for MRI Contrast Agents

2017 ◽  
Vol 24 (5) ◽  
pp. 470-482 ◽  
Author(s):  
Nicolas Alcaraz ◽  
Ben J. Boyd
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

2021 ◽  
Author(s):  
Anton Popov ◽  
Maxim Artemovich Abakumov ◽  
Irina Savintseva ◽  
Artem Ermakov ◽  
Nelly Popova ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Selective Cytotoxicity ◽  
Magnetic Resonance Imaging Mri

Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

scholarly journals Correction to: Magnetic Nanoparticles as MRI Contrast Agents

2021 ◽  
Vol 379 (4) ◽  
Author(s):  
Ashish Avasthi ◽  
Carlos Caro ◽  
Esther Pozo-Torres ◽  
Manuel Pernia Leal ◽  
María Luisa García-Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast

A correction to this paper has been published: https://doi.org/10.1007/s41061-021-00340-y

One-Step Synthesis of Single-Stranded DNA-Bridged Iron Oxide Supraparticles as MRI Contrast Agents

Nano Letters ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2793-2799
Author(s):  
Jingfang Zhang ◽  
Zhenghan Di ◽  
Husheng Yan ◽  
Yuliang Zhao ◽  
Lele Li
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Single Stranded Dna ◽  
Mri Contrast ◽  
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