scholarly journals Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

2012 ◽  
Vol 134 (25) ◽  
pp. 10385-10388 ◽  
Author(s):  
Justin S. Cisar ◽  
Benjamin F. Cravatt
Keyword(s):  
Small Molecule ◽  
Target Identification ◽  
Phenotypic Screening ◽  
Small Molecule Probes

Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy

2014 ◽  
Vol 126 (20) ◽  
pp. 5202-5206 ◽  
Author(s):  
Minseob Koh ◽  
Jongmin Park ◽  
Ja Young Koo ◽  
Donghyun Lim ◽  
Mi Young Cha ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Small Molecule ◽  
Target Identification ◽  
Phenotypic Screening ◽  
Small Molecule Enhancers

scholarly journals Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

2021 ◽  
Vol 50 (2) ◽  
pp. 702-734
Author(s):  
Luling Wu ◽  
Jihong Liu ◽  
Ping Li ◽  
Bo Tang ◽  
Tony D. James
Keyword(s):  
Small Molecule ◽  
Biological Systems ◽  
Two Photon ◽  
Small Molecule Probes ◽  
Recent Advances ◽  
Design Construction

In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes.

Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators

2021 ◽  
Vol 28 (3) ◽  
pp. 283-299
Author(s):  
Nil Ege ◽  
Habib Bouguenina ◽  
Marianthi Tatari ◽  
Rajesh Chopra
Keyword(s):  
Target Identification ◽  
E3 Ligase ◽  
Phenotypic Screening
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