Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

2021 ◽  
Author(s):  
Sida Shen ◽  
Arseniy Butrin ◽  
Peter F. Doubleday ◽  
Rafael D. Melani ◽  
Brett A. Beaupre ◽  
...  
Keyword(s):  
Ornithine Aminotransferase ◽  
Selective Mechanism

scholarly journals Point Mutation Affecting Processing of the Ornithine Aminotransferase Precursor Protein in Gyrate Atrophy

1989 ◽  
Vol 264 (29) ◽  
pp. 17432-17436
Author(s):  
G Inana ◽  
C Chambers ◽  
Y Hotta ◽  
L Inouye ◽  
D Filpula ◽  
...  
Keyword(s):  
Point Mutation ◽  
Precursor Protein ◽  
Ornithine Aminotransferase ◽  
Gyrate Atrophy

scholarly journals A heritable variant of mouse liver ornithine aminotransferase (EC 2.6.1.13) induced by ethylnitrosourea.

1988 ◽  
Vol 263 (30) ◽  
pp. 15781-15784
Author(s):  
C S Giometti ◽  
S L Tollaksen ◽  
M A Gemmell ◽  
J Burcham ◽  
C Peraino
Keyword(s):  
Mouse Liver ◽  
Ornithine Aminotransferase

scholarly journals Regulation of Ornithine Aminotransferase in Retinoblastomas

1989 ◽  
Vol 264 (34) ◽  
pp. 20513-20517
Author(s):  
R.J. Fagan ◽  
W.P. Sheffield ◽  
R Rozen
Keyword(s):  
Ornithine Aminotransferase

Turnover of total proteins and ornithine aminotransferase during liver regeneration in rats

1980 ◽  
Vol 238 (1) ◽  
pp. E46-E52
Author(s):  
S. L. Augustine ◽  
R. W. Swick
Keyword(s):  
Amino Acids ◽  
Liver Regeneration ◽  
Protein Degradation ◽  
Partial Hepatectomy ◽  
Free Amino ◽  
Liver Protein ◽  
Ornithine Aminotransferase ◽  
Fractional Rate

The recovery of approximately 40% of the total liver protein during the first day after partial hepatectomy was shown to be due to the near cessation of protein breakdown rather than to an increase in protein synthesis. The decrease in degradation of total protein was less if rats were adrenalectomized or protein-depleted prior to partial hepatectomy. The effect of these treatments originally suggested that changes in free amino acid levels in liver might be related to the rate of protein degradation. However, no correlation was found between levels of total free amino acids and rates of breakdown. Measurements of individual amino acids during liver regeneration suggested that levels of free methionine and phenylalanine, amino acids that have been found to lower rates of protein degradation in vitro, are not correlated with rates of breakdown in vivo. The difference between the fractional rate of ornithine aminotransferase degradation (0.68/day and 0.28/day in sham-hepatectomized and partially hepatectomized rats, respectively) was sufficient to account for the higher level of this protein 3 days after surgery in the latter group.

scholarly journals ERK2 Shows a Restrictive and Locally Selective Mechanism of Recognition by Its Tyrosine Phosphatase Inactivators Not Shared by Its Activator MEK1

2005 ◽  
Vol 280 (45) ◽  
pp. 37885-37894 ◽  
Author(s):  
Céline Tárrega ◽  
Pablo Ríos ◽  
Rocío Cejudo-Marín ◽  
Carmen Blanco-Aparicio ◽  
Lieke van den Berk ◽  
...  
Keyword(s):  
Tyrosine Phosphatase ◽  
Mechanism Of Recognition ◽  
Selective Mechanism
Sign in / Sign up

Export Citation Format

Share Document