Application of Native Ion Exchange Mass Spectrometry to Intact and Subunit Analysis of Site-Specific Antibody–Drug Conjugates Produced by AJICAP First Generation Technology

2020 ◽  
Vol 31 (8) ◽  
pp. 1706-1712 ◽  
Author(s):  
Yutaka Matsuda ◽  
Michal Kliman ◽  
Brian A. Mendelsohn
Keyword(s):  
Mass Spectrometry ◽  
Ion Exchange ◽  
Specific Antibody ◽  
First Generation ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Exchange Mass Spectrometry ◽  
Drug Conjugates ◽  
Generation Technology ◽  
Antibody Drug

scholarly journals Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates

mAbs ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 801-811 ◽  
Author(s):  
Thomas Botzanowski ◽  
Stéphane Erb ◽  
Oscar Hernandez-Alba ◽  
Anthony Ehkirch ◽  
Olivier Colas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Specific Antibody ◽  
Native Mass Spectrometry ◽  
Middle Level ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Abstract 752: CovisoLinK: New bacterial transglutaminase Q-Tag substrate for the development of site specific antibody-drug conjugates

2018 ◽  
Author(s):  
Eva Sivado ◽  
Vincent Thomas ◽  
Meddy El Alaoui ◽  
Anne-Catherine Jallas ◽  
Mike R. Dyson ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

2016 ◽  
Vol 138 (4) ◽  
pp. 1430-1445 ◽  
Author(s):  
Jeffrey C. Kern ◽  
Mark Cancilla ◽  
Deborah Dooney ◽  
Kristen Kwasnjuk ◽  
Rena Zhang ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Abstract 644: Impact of conjugation site on pharmacokinetics and off-target toxicity of site-specific antibody drug conjugates

2015 ◽  
Author(s):  
Dangshe Ma ◽  
Fang Jin ◽  
Frank Barletta ◽  
George Hu ◽  
Nathan Tumey ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

scholarly journals Site-specific antibody drug conjugates for cancer therapy

mAbs ◽  
2013 ◽  
Vol 6 (1) ◽  
pp. 34-45 ◽  
Author(s):  
Siler Panowski ◽  
Sunil Bhakta ◽  
Helga Raab ◽  
Paul Polakis ◽  
Jagath R Junutula
Keyword(s):  
Cancer Therapy ◽  
Specific Antibody ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy

2021 ◽  
Author(s):  
Zhefu Dai ◽  
Xiao-Nan Zhang ◽  
Qinqin Cheng ◽  
Fan Fei ◽  
Tianling Hou ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Corrigendum to “A chemoenzymatic approach toward the preparation of site-specific antibody–drug conjugates” [Tetrahedron Lett. 56 (2015) 3172–3175]

2015 ◽  
Vol 56 (34) ◽  
pp. 4960 ◽  
Author(s):  
Xiaoqing Cai ◽  
Daniel Globisch ◽  
Pamela Thompson ◽  
Jia Lin ◽  
Dorin Toader ◽  
...  
Keyword(s):  
Specific Antibody ◽  
Site Specific ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug
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