Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies

Milos Cejkov; Tyler Greer; Reid O’Brien Johnson; Xiaojing Zheng; Ning Li

doi:10.1021/jasms.0c00458

Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies

Journal of the American Society for Mass Spectrometry ◽

10.1021/jasms.0c00458 ◽

2021 ◽

Vol 32 (3) ◽

pp. 762-771

Author(s):

Milos Cejkov ◽

Tyler Greer ◽

Reid O’Brien Johnson ◽

Xiaojing Zheng ◽

Ning Li

Keyword(s):

Electron Transfer ◽

Monoclonal Antibodies ◽

Design Of Experiments ◽

Parameter Optimization ◽

Electron Transfer Dissociation ◽

Sequence Coverage

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Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac4036857 ◽

2014 ◽

Vol 86 (6) ◽

pp. 3005-3012 ◽

Cited By ~ 119

Author(s):

Luca Fornelli ◽

Daniel Ayoub ◽

Konstantin Aizikov ◽

Alain Beck ◽

Yury O. Tsybin

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

Fourier Transform ◽

Monoclonal Antibodies ◽

Electron Transfer Dissociation ◽

Fourier Transform Mass Spectrometry

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Characterization and Comparison of Disulfide Linkages and Scrambling Patterns in Therapeutic Monoclonal Antibodies: Using LC-MS with Electron Transfer Dissociation

Analytical Chemistry ◽

10.1021/ac200128d ◽

2011 ◽

Vol 83 (8) ◽

pp. 3133-3140 ◽

Cited By ~ 76

Author(s):

Yi Wang ◽

Qiaozhen Lu ◽

Shiaw-Lin Wu ◽

Barry L. Karger ◽

William S. Hancock

Keyword(s):

Electron Transfer ◽

Monoclonal Antibodies ◽

Electron Transfer Dissociation ◽

Disulfide Linkages ◽

Therapeutic Monoclonal Antibodies

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Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-020-02409-x ◽

2020 ◽

Vol 412 (7) ◽

pp. 1693-1700 ◽

Cited By ~ 4

Author(s):

Richard Y.-C. Huang ◽

Michelle Kuhne ◽

Shrikant Deshpande ◽

Vangipuram Rangan ◽

Mohan Srinivasan ◽

...

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

Monoclonal Antibodies ◽

Major Histocompatibility Complex ◽

Major Histocompatibility Complex Class ◽

Electron Transfer Dissociation ◽

Hydrogen Deuterium Exchange ◽

Complex Class ◽

Histocompatibility Complex ◽

Hydrogen Deuterium

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Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac201293m ◽

2011 ◽

Vol 83 (23) ◽

pp. 8919-8927 ◽

Cited By ~ 107

Author(s):

Yury O. Tsybin ◽

Luca Fornelli ◽

Carsten Stoermer ◽

Markus Luebeck ◽

Julien Parra ◽

...

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

Monoclonal Antibodies ◽

Structural Analysis ◽

Electron Transfer Dissociation

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Protein derivatization and sequential ion/ion reactions to enhance sequence coverage produced by electron transfer dissociation mass spectrometry

International Journal of Mass Spectrometry ◽

10.1016/j.ijms.2014.06.023 ◽

2015 ◽

Vol 377 ◽

pp. 617-624 ◽

Cited By ~ 18

Author(s):

Lissa C. Anderson ◽

A. Michelle English ◽

Wei-Han Wang ◽

Dina L. Bai ◽

Jeffrey Shabanowitz ◽

...

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

Electron Transfer Dissociation ◽

Sequence Coverage

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GNSS Patch Antenna Design Parameter Optimization using FEKO, Design of Experiments & P-Transform Technique

2021 International Conference on Advances in Electrical, Computing, Communication and Sustainable Technologies (ICAECT) ◽

10.1109/icaect49130.2021.9392511 ◽

2021 ◽

Author(s):

Gholam D Aghashirin ◽

Maged Kafafy ◽

Hoda S. Abdel-Aty-Zohdy ◽

Mohamed A. Zohdy ◽

Adam Timmons

Keyword(s):

Design Of Experiments ◽

Parameter Optimization ◽

Patch Antenna ◽

Design Parameter ◽

Antenna Design

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Characterization and Quantification of Highly Sulfated Glycosaminoglycan Isomers by Gated-Trapped Ion Mobility Spectrometry Negative Electron Transfer Dissociation MS/MS

Analytical Chemistry ◽

10.1021/acs.analchem.8b05283 ◽

2019 ◽

Vol 91 (4) ◽

pp. 2994-3001 ◽

Cited By ~ 18

Author(s):

Juan Wei ◽

Jiandong Wu ◽

Yang Tang ◽

Mark E. Ridgeway ◽

Melvin A. Park ◽

...

Keyword(s):

Electron Transfer ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

Electron Transfer Dissociation ◽

Trapped Ion ◽

Sulfated Glycosaminoglycan ◽

Trapped Ion Mobility Spectrometry ◽

Negative Electron Transfer Dissociation

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Application of electron transfer dissociation mass spectrometry in analyses of non-enzymatically glycated peptides

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2884 ◽

2007 ◽

Vol 21 (5) ◽

pp. 661-666 ◽

Cited By ~ 60

Author(s):

Qibin Zhang ◽

Andrej Frolov ◽

Ning Tang ◽

Ralf Hoffmann ◽

Tom van de Goor ◽

...

Keyword(s):

Mass Spectrometry ◽

Electron Transfer ◽

Electron Transfer Dissociation

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In Silico Reagent Design for Electron-Transfer Dissociation on a Q-TOF

Journal of the American Society for Mass Spectrometry ◽

10.1021/jasms.0c00483 ◽

2021 ◽

Author(s):

Keith Richardson ◽

Jeffery Brown

Keyword(s):

Electron Transfer ◽

In Silico ◽

Electron Transfer Dissociation

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Trans-Proteomic Pipeline supports and improves analysis of electron transfer dissociation data sets

PROTEOMICS ◽

10.1002/pmic.200900567 ◽

2010 ◽

Vol 10 (6) ◽

pp. 1190-1195 ◽

Cited By ~ 30

Author(s):

Eric W. Deutsch ◽

David Shteynberg ◽

Henry Lam ◽

Zhi Sun ◽

Jimmy K. Eng ◽

...

Keyword(s):

Electron Transfer ◽

Electron Transfer Dissociation ◽

Data Sets

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