scholarly journals Characterization and Comparison of Disulfide Linkages and Scrambling Patterns in Therapeutic Monoclonal Antibodies: Using LC-MS with Electron Transfer Dissociation

2011 ◽  
Vol 83 (8) ◽  
pp. 3133-3140 ◽  
Author(s):  
Yi Wang ◽  
Qiaozhen Lu ◽  
Shiaw-Lin Wu ◽  
Barry L. Karger ◽  
William S. Hancock
Keyword(s):  
Electron Transfer ◽  
Monoclonal Antibodies ◽  
Electron Transfer Dissociation ◽  
Disulfide Linkages ◽  
Therapeutic Monoclonal Antibodies

Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies

2021 ◽  
Vol 32 (3) ◽  
pp. 762-771
Author(s):  
Milos Cejkov ◽  
Tyler Greer ◽  
Reid O’Brien Johnson ◽  
Xiaojing Zheng ◽  
Ning Li
Keyword(s):  
Electron Transfer ◽  
Monoclonal Antibodies ◽  
Design Of Experiments ◽  
Parameter Optimization ◽  
Electron Transfer Dissociation ◽  
Sequence Coverage

Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

2014 ◽  
Vol 86 (6) ◽  
pp. 3005-3012 ◽  
Author(s):  
Luca Fornelli ◽  
Daniel Ayoub ◽  
Konstantin Aizikov ◽  
Alain Beck ◽  
Yury O. Tsybin
Keyword(s):  
Mass Spectrometry ◽  
Electron Transfer ◽  
Fourier Transform ◽  
Monoclonal Antibodies ◽  
Electron Transfer Dissociation ◽  
Fourier Transform Mass Spectrometry

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

2011 ◽  
Vol 83 (23) ◽  
pp. 8919-8927 ◽  
Author(s):  
Yury O. Tsybin ◽  
Luca Fornelli ◽  
Carsten Stoermer ◽  
Markus Luebeck ◽  
Julien Parra ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Transfer ◽  
Monoclonal Antibodies ◽  
Structural Analysis ◽  
Electron Transfer Dissociation

scholarly journals Mass Spectrometric Determination of Disulfide Linkages in Recombinant Therapeutic Proteins Using Online LC−MS with Electron-Transfer Dissociation

2009 ◽  
Vol 81 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Shiaw-Lin Wu ◽  
Haitao Jiang ◽  
Qiaozhen Lu ◽  
Shujia Dai ◽  
William S. Hancock ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Electron Transfer Dissociation ◽  
Therapeutic Proteins ◽  
Mass Spectrometric ◽  
Mass Spectrometric Determination ◽  
Disulfide Linkages

Design of Innovative Therapeutic Monoclonal Antibodies

2017 ◽  
pp. 10-29
Author(s):  
A.V. Karabelskii ◽  
◽  
T.A. Nemankin ◽  
A.B. Ulitin ◽  
A.S. Vaganov ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies in Clinical Practice against Cancer

2020 ◽  
Vol 20 (16) ◽  
pp. 1895-1907
Author(s):  
Navgeet Kaur ◽  
Anju Goyal ◽  
Rakesh K. Sindhu
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Clinical Practice ◽  
Therapeutic Agent ◽  
Hematologic Malignancies ◽  
Immune Checkpoints ◽  
Malignant Cells ◽  
Main Target ◽  
Therapeutic Monoclonal Antibodies ◽  
Cancerous Cells

The importance of monoclonal antibodies in oncology has increased drastically following the discovery of Milstein and Kohler. Since the first approval of the monoclonal antibody, i.e. Rituximab in 1997 by the FDA, there was a decline in further applications but this number has significantly increased over the last three decades for various therapeutic applications due to the lesser side effects in comparison to the traditional chemotherapy methods. Presently, numerous monoclonal antibodies have been approved and many are in queue for approval as a strong therapeutic agent for treating hematologic malignancies and solid tumors. The main target checkpoints for the monoclonal antibodies against cancer cells include EGFR, VEGF, CD and tyrosine kinase which are overexpressed in malignant cells. Other immune checkpoints like CTLA-4, PD-1 and PD-1 receptors targeted by the recently developed antibodies increase the capability of the immune system in destroying the cancerous cells. Here, in this review, the mechanism of action, uses and target points of the approved mAbs against cancer have been summarized.

scholarly journals COVID-19: Unmasking Emerging SARS-CoV-2 Variants, Vaccines and Therapeutic Strategies

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 993
Author(s):  
Renuka Raman ◽  
Krishna J. Patel ◽  
Kishu Ranjan
Keyword(s):  
Immune Response ◽  
Monoclonal Antibodies ◽  
Severe Acute Respiratory Syndrome ◽  
Small Molecules ◽  
Viral Vector ◽  
Therapeutic Strategies ◽  
Convincing Evidence ◽  
Plasma Therapy ◽  
Therapeutic Monoclonal Antibodies ◽  
Increased Susceptibility

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, which has been a topic of major concern for global human health. The challenge to restrain the COVID-19 pandemic is further compounded by the emergence of several SARS-CoV-2 variants viz. B.1.1.7 (Alpha), B.1.351 (Beta), P1 (Gamma) and B.1.617.2 (Delta), which show increased transmissibility and resistance towards vaccines and therapies. Importantly, there is convincing evidence of increased susceptibility to SARS-CoV-2 infection among individuals with dysregulated immune response and comorbidities. Herein, we provide a comprehensive perspective regarding vulnerability of SARS-CoV-2 infection in patients with underlying medical comorbidities. We discuss ongoing vaccine (mRNA, protein-based, viral vector-based, etc.) and therapeutic (monoclonal antibodies, small molecules, plasma therapy, etc.) modalities designed to curb the COVID-19 pandemic. We also discuss in detail, the challenges posed by different SARS-CoV-2 variants of concern (VOC) identified across the globe and their effects on therapeutic and prophylactic interventions.

scholarly journals Application of electron transfer dissociation mass spectrometry in analyses of non-enzymatically glycated peptides

2007 ◽  
Vol 21 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Qibin Zhang ◽  
Andrej Frolov ◽  
Ning Tang ◽  
Ralf Hoffmann ◽  
Tom van de Goor ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Transfer ◽  
Electron Transfer Dissociation
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