Pharmacokinetics of a Slow-Release Formulation of Soybean Isoflavones in Healthy Postmenopausal Women

2005 ◽  
Vol 53 (6) ◽  
pp. 1938-1944 ◽  
Author(s):  
Kenneth D. R. Setchell ◽  
Amnon Brzezinski ◽  
Nadine M. Brown ◽  
Pankaj B. Desai ◽  
Murad Melhem ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Slow Release ◽  
Release Formulation ◽  
Soybean Isoflavones ◽  
Slow Release Formulation

scholarly journals Mesalazine (5-aminosalicylic acid) induced chronic hepatitis

Gut ◽  
1999 ◽  
Vol 44 (6) ◽  
pp. 886-888 ◽  
Author(s):  
P Deltenre ◽  
A Berson ◽  
P Marcellin ◽  
C Degott ◽  
M Biour ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Side Effects ◽  
Adverse Effects ◽  
Liver Dysfunction ◽  
Liver Enzymes ◽  
Slow Release ◽  
Aminosalicylic Acid ◽  
Safe Alternative ◽  
Release Formulation ◽  
Slow Release Formulation

BACKGROUNDTreatment of ulcerative colitis or Crohn’s disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow release formulation of 5-aminosalicylic acid, was expected to be a safe alternative. However, several cases of acute hepatitis have been reported.CASE REPORTA 65 year old man had increased liver enzymes, anti-nuclear and anti-smooth muscle autoantibodies and IgG levels, and lesions of chronic hepatitis after 21 months of mesalazine treatment. Although liver dysfunction had been identified eight months earlier, simvastatin rather than mesalazine had been withdrawn, without any improvement. In contrast, liver enzyme and IgG levels became normal and autoantibodies disappeared after discontinuation of mesalazine administration.CONCLUSIONContrary to initial expectations, mesalazine can cause most of the sulphasalazine induced adverse effects, and hepatic side effects may be almost as frequent. When liver dysfunction occurs, mesalazine administration should be discontinued to avoid the development of chronic hepatitis and liver fibrosis.

Pharmacokinetics of 5-aminosalicylic acid in man following administration of intravenous bolus andper os slow-release formulation

1991 ◽  
Vol 36 (12) ◽  
pp. 1735-1740 ◽  
Author(s):  
S. Bondesen ◽  
J. Hegnh�j ◽  
F. Larsen ◽  
S. Honor� Hansen ◽  
C. P. Hansen ◽  
...  
Keyword(s):  
Slow Release ◽  
Intravenous Bolus ◽  
Aminosalicylic Acid ◽  
Release Formulation ◽  
Slow Release Formulation

slow release formulation (SR)

2009 ◽  
pp. 170-170
Author(s):  
Gerhard Nahler
Keyword(s):  
Slow Release ◽  
Release Formulation ◽  
Slow Release Formulation

scholarly journals Development and Laboratory Evaluation of a Slow Release Formulation of Fipronil against Subterranean Termites (Odontotermes obesus Rambur)

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Sajid Amin Sarmad ◽  
Muhammad Zeeshan Majeed ◽  
Muhammad Luqman ◽  
Muhammad Asam Riaz ◽  
Sohail Ahmed ◽  
...  
Keyword(s):  
Slow Release ◽  
Laboratory Evaluation ◽  
Subterranean Termites ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
Odontotermes Obesus

Depronal SA: sustained-action dextropropoxyphene

1972 ◽  
Vol 10 (10) ◽  
pp. 40-40
Keyword(s):  
Analgesic Effect ◽  
Slow Release ◽  
Narcotic Drug ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
Sustained Action

Depronal SA is a slow-release formulation of dextropropoxyphene,1 a synthetic non-narcotic drug with about the same analgesic effect as codeine. The drug is available alone as 65 mg capsules (Doloxene) and also mixed with various other drugs, e.g. as Doloxene Co-65 (with aspirin, phenacetin and caffeine) and as Distalgesic (with paracetamol).

scholarly journals 1085 – Neuronal Serotonin As a Link Between Depression and Constipation: A Role for Simultaneous Treatment with a Novel Slow-Release Formulation of the Serotonin Precursor, 5-Hydroxytryptophan

2019 ◽  
Vol 156 (6) ◽  
pp. S-229-S-230
Author(s):  
Andrew Del Colle ◽  
Narek Israelyan ◽  
Zhishan Li ◽  
Yeji Park ◽  
Ruth Ann Luna ◽  
...  
Keyword(s):  
Slow Release ◽  
Simultaneous Treatment ◽  
Release Formulation ◽  
Slow Release Formulation

scholarly journals IgG-Mediated Anaphylaxis to a Synthetic Long Peptide Vaccine Containing a B Cell Epitope Can Be Avoided by Slow-Release Formulation

2014 ◽  
Vol 192 (12) ◽  
pp. 5813-5820 ◽  
Author(s):  
Esther D. Quakkelaar ◽  
Marieke F. Fransen ◽  
Wendy W. C. van Maren ◽  
Joost Vaneman ◽  
Nikki M. Loof ◽  
...  
Keyword(s):  
B Cell ◽  
Slow Release ◽  
Peptide Vaccine ◽  
Cell Epitope ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
B Cell Epitope

THE EFFECT OF A SLOW-RELEASE FORMULATION OF ZUCLOPENTHIXOL ACETATE (ACUNIL®) ON CAPTIVE BLUE WILDEBEEST (CONNOCHAETES TAURINUS) BEHAVIOR AND PHYSIOLOGICAL RESPONSE

2016 ◽  
Vol 47 (2) ◽  
pp. 514-522 ◽  
Author(s):  
Liesel L. Laubscher ◽  
Louwrens C. Hoffman ◽  
Neville I. Pitts ◽  
Jacobus P. Raath
Keyword(s):  
Physiological Response ◽  
Slow Release ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
Connochaetes Taurinus
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