Tyrosine kinase inhibitors. 7. 7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

New Class ◽

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 7. 7-Amino-4-(phenylamino)- and 7- Amino-4-((phenylmethyl)amino)pyrido(4,3-d)pyrimidines: A New Class of Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor.

ChemInform ◽

10.1002/chin.199603160 ◽

2010 ◽

Vol 27 (3) ◽

pp. no-no

Author(s):

A. M. THOMPSON ◽

A. J. BRIDGES ◽

D. W. FRY ◽

A. J. KRAKER ◽

W. A. DENNY

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

New Class ◽

Tyrosine Kinase Inhibitors. 13. Structure−Activity Relationships for Soluble 7-Substituted 4-[(3-Bromophenyl)amino]pyrido[4,3-d]pyrimidines Designed as Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm970366v ◽

1997 ◽

Vol 40 (24) ◽

pp. 3915-3925 ◽

Cited By ~ 43

Author(s):

Andrew M. Thompson ◽

Donna K. Murray ◽

William L. Elliott ◽

David W. Fry ◽

James A. Nelson ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Structure Activity ◽

ChemInform Abstract: Tyrosine Kinase Inhibitors. Part 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR).

ChemInform ◽

10.1002/chin.199623160 ◽

2010 ◽

Vol 27 (23) ◽

pp. no-no

Author(s):

G. W. REWCASTLE ◽

B. D. PALMER ◽

A. J. BRIDGES ◽

H. D. H. SHOWALTER ◽

L. SUN ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm950692f ◽

1996 ◽

Vol 39 (4) ◽

pp. 918-928 ◽

Cited By ~ 107

Author(s):

Gordon W. Rewcastle ◽

Brian D. Palmer ◽

Alexander J. Bridges ◽

H. D. Hollis Showalter ◽

Li Sun ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Activity ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Effect of Membrane Fluidity on Tyrosine Kinase Activity of Reconstituted Epidermal Growth Factor Receptor

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.2001.4600 ◽

2001 ◽

Vol 282 (2) ◽

pp. 511-514 ◽

Cited By ~ 21

Author(s):

Gaoxiang Ge ◽

Jing Wu ◽

Qishui Lin

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Membrane Fluidity ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin

Biochemical Pharmacology ◽

10.1016/0006-2952(93)90633-8 ◽

1993 ◽

Vol 46 (11) ◽

pp. 1929-1936 ◽

Cited By ~ 50

Author(s):

P. de Witte ◽

P. Agostinis ◽

J. Van Lint ◽

W. Merlevede ◽

J.R. Vandenheede

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Effect of carboxyl terminal truncation on the tyrosine kinase activity of the epidermal growth factor receptor

Archives of Biochemistry and Biophysics ◽

10.1016/0003-9861(92)90079-c ◽

1992 ◽

Vol 292 (1) ◽

pp. 273-280 ◽

Cited By ~ 9

Author(s):

Philip B. Wedegaertner ◽

Gordon N. Gill

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Carboxyl Terminal

Evidence for the potentiation of epidermal growth factor receptor tyrosine kinase activity by association with the detergent-insoluble cellular cytoskeleton: analysis of intact and carboxy-terminally truncated receptors.

Endocrinology ◽

10.1210/endo.133.6.8243311 ◽

1993 ◽

Vol 133 (6) ◽

pp. 2838-2846 ◽

Cited By ~ 14

Author(s):

A M Gronowski ◽

P J Bertics

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Cellular Cytoskeleton

Epidermal growth factor receptor tyrosine kinase activity in psoriasis lesions

Journal of the European Academy of Dermatology and Venereology ◽

10.1016/s0926-9959(98)95705-1 ◽

1998 ◽

Vol 11 ◽

pp. S294

Author(s):

R MITURSKI

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

FEBS Letters ◽

10.1016/0014-5793(93)81704-4 ◽

1993 ◽

Vol 334 (2) ◽

pp. 161-164 ◽

Cited By ~ 107

Author(s):

Thomas Mattar ◽

Kulvinder Kochhar ◽

Robert Bartlett ◽

Eric G. Bremer ◽

Alison Finnegan

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Kinase Activity ◽

Growth Factor Receptor ◽