Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogs in the C2-methyl series

1991 ◽  
Vol 34 (7) ◽  
pp. 2209-2218 ◽  
Author(s):  
Peter R. Marsham ◽  
Ann L. Jackman ◽  
Anthony J. Hayter ◽  
Melanie R. Daw ◽  
Jayne L. Snowden ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
Conformationally Restricted ◽  
Thymidylate Synthase Inhibitors ◽  
Conformationally Restricted Analogs

Thymidylate synthase inhibitors: The in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

1991 ◽  
Vol 31 ◽  
pp. 13-27 ◽  
Author(s):  
A.L. Jackman ◽  
P.R. Marsham ◽  
R.G. Moran ◽  
R. Kimbell ◽  
B.M. O'Connor ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Thymidylate Synthase Inhibitors

Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

2003 ◽  
Vol 52 (0) ◽  
pp. 80-89 ◽  
Author(s):  
Edward Chu ◽  
Marc A. Callender ◽  
Michael P. Farrell ◽  
John C. Schmitz
Keyword(s):  
Thymidylate Synthase ◽  
Anticancer Agents ◽  
Thymidylate Synthase Inhibitors

Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells

2021 ◽  
pp. 116136
Author(s):  
Mohammad Mahboob Alam ◽  
Azizah M. Malebari ◽  
Syed Nazreen ◽  
Thikryat Neamatallah ◽  
Abdulraheem SA Almalki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Docking ◽  
Cancer Cells ◽  
Thymidylate Synthase ◽  
Breast Cancer Cells ◽  
Docking Studies ◽  
Design Synthesis ◽  
Molecular Docking Studies ◽  
Thymidylate Synthase Inhibitors

A 3 dimensional model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogs of 8-hydroxy-2-(dipropylamino)tetralin

1991 ◽  
Vol 34 (2) ◽  
pp. 497-510 ◽  
Author(s):  
Charlotta Mellin ◽  
Jerk Vallgaarda ◽  
David L. Nelson ◽  
Lena Bjoerk ◽  
Hong Yu ◽  
...  
Keyword(s):  
Dimensional Model ◽  
3 Dimensional ◽  
Receptor Agonists ◽  
Conformationally Restricted ◽  
Conformationally Restricted Analogs

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

2000 ◽  
Vol 8 (5) ◽  
pp. 1075-1086 ◽  
Author(s):  
Dale L. Boger ◽  
Marc A. Labroli ◽  
Thomas H. Marsilje ◽  
Qing Jin ◽  
Michael P. Hedrick ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Selective Inhibition ◽  
Conformationally Restricted ◽  
Gar Tfase

Mechanisms of Acquired Resistance to Thymidylate Synthase Inhibitors: The Role of Enzyme Stability

1999 ◽  
Vol 56 (5) ◽  
pp. 1063-1070 ◽  
Author(s):  
Maria E. Kitchens ◽  
Antonia M. Forsthoefel ◽  
Karen W. Barbour ◽  
H. Trent Spencer ◽  
Franklin G. Berger
Keyword(s):  
Thymidylate Synthase ◽  
Enzyme Stability ◽  
Acquired Resistance ◽  
Thymidylate Synthase Inhibitors

Folate-based thymidylate synthase inhibitors in cancer chemotherapy

1997 ◽  
Vol 8 (1) ◽  
pp. 3-16 ◽  
Author(s):  
Yuzuru Takemura ◽  
Ann L. Jackman
Keyword(s):  
Cancer Chemotherapy ◽  
Thymidylate Synthase ◽  
Thymidylate Synthase Inhibitors

Role of P53 Status on Sensitivity to Thymidylate Synthase Inhibitors and Induction of Apoptosis

2002 ◽  
pp. 433-437
Author(s):  
H. H. J. Backus ◽  
H. M. Pinedo ◽  
D. Wouters ◽  
M. C. Koudijs ◽  
C. G. Ferreira ◽  
...  
Keyword(s):  
Thymidylate Synthase ◽  
P53 Status ◽  
Induction Of Apoptosis ◽  
Thymidylate Synthase Inhibitors
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