Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids [Erratum to document cited in CA108(11):94432r]

1988 ◽  
Vol 31 (11) ◽  
pp. 2227-2227 ◽  
Author(s):  
David B. Kanne ◽  
Leo G. Abood
Keyword(s):  
Biological Characterization ◽  
Structure Activity Relationships ◽  
Conformationally Restricted ◽  
Structure Activity

Structure–Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist

2017 ◽  
Vol 60 (23) ◽  
pp. 9641-9652 ◽  
Author(s):  
Salvatore Di Maro ◽  
Francesco Saverio Di Leva ◽  
Anna Maria Trotta ◽  
Diego Brancaccio ◽  
Luigi Portella ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Receptor Type ◽  
Biological Characterization ◽  
Cxcr4 Antagonist ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Phytotoxic Terpenes Produced by Phytopathogenic Fungi and Allelopathic Plants

2014 ◽  
Vol 9 (3) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Alessio Cimmino ◽  
Anna Andolfi ◽  
Antonio Evidente
Keyword(s):  
Mode Of Action ◽  
Potential Application ◽  
Fungal Pathogens ◽  
Phytopathogenic Fungi ◽  
Biological Characterization ◽  
Anticancer Compounds ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Forest Plants

This review is about the isolation as well as chemical and biological characterization of simple and complex mono-, sesqui-, di-, sester- and tri-terpenes produced by fungal pathogens of agrarian and forest plants and by some allelopathic plants. In several cases, the structure activity relationships are also discussed, as well as their potential application in agriculture as natural safe herbicides, fungicides and bactericides. Furthermore, the potential application of some fungal terpenes as anticancer compounds with a new mode of action is also discussed.

scholarly journals Biological Characterization, Mechanistic Investigation and Structure‐Activity Relationships of Chemically Stable TLR2 Antagonists

ChemMedChem ◽  
2020 ◽  
Vol 15 (14) ◽  
pp. 1364-1371 ◽  
Author(s):  
Marcel Bermudez ◽  
Maria Grabowski ◽  
Manuela S. Murgueitio ◽  
Markus Tiemann ◽  
Péter Varga ◽  
...  
Keyword(s):  
Biological Characterization ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Mechanistic Investigation

scholarly journals Characterization of platinum(II) complexes exhibiting inhibitory activity against the 20S proteasome

2020 ◽  
Vol 7 (8) ◽  
pp. 200545
Author(s):  
Tatsuto Kiwada ◽  
Hiromu Katakasu ◽  
Serina Okumura ◽  
Akira Odani
Keyword(s):  
Inhibitory Activity ◽  
Chemical Structure ◽  
Competitive Inhibition ◽  
Proteasome Inhibitors ◽  
Platinum Complex ◽  
Platinum Complexes ◽  
Binding Mode ◽  
Structure Activity Relationships ◽  
Structure Activity

Proteasome inhibitors are useful for biochemical research and clinical treatment. In our previous study, we reported that the 4N-coordinated platinum complexes with anthracenyl ring and heterocycle exhibited proteasome-inhibitory activity. In the present study, the structure–activity relationships and characterization of these complexes were determined for the elucidation of the role of aromatic ligands. Lineweaver–Burk analysis revealed that the chemical structure of heterocycles affects the binding mode of platinum complexes. Platinum complexes with anthracenyl ring and pyridine showed competitive inhibition, although platinum complexes with anthracenyl ring and phenanthroline showed non-competitive inhibition. The structure–activity relationships demonstrated that anthracenyl moiety plays a crucial role in proteasome-inhibitory activity. The platinum complexes with naphthyl or phenyl rings exhibited lower inhibitory activities than the platinum complex with anthracenyl ring. The reactivity with N-acetylcysteine varied according to the chemical structure of complexes.

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